{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:11:55Z","timestamp":1767867115936,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Identification of people living with hepatitis C virus (HCV) via readily available laboratory records could be a key strategy for macro\u2010elimination, aligning with the WHO elimination goal. Therefore, the ELIMINATE(ELIMINation of HCV in AusTria East) project aimed to systematically re\u2010link people with a \u2018last\u2010positive\u2019 HCV\u2010RNA PCR record to care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 10 major liver centres in Eastern Austria, a systematic readout of \u2018last\u2010positive\u2019 HCV\u2010RNA PCR test records obtained between 2008 and 2020 were conducted and linked to available patient contact data. Between 2020 and 2023, individuals were contacted first by phone, then by letter, to inform them about the availability of effective direct\u2010acting antiviral (DAA) treatment and invite them for pre\u2010treatment evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall cohort of last\u2010positive HCV+ individuals included 5695 subjects (62.5% males, mean age 57.3\u2009\u00b1\u200917.3\u2009years); of note, 1931 (34%) of them had died and 759 (13%) individuals had no valid contact information. Of the remaining 3005 individuals, 1171 (40.0%) had already achieved sustained virological response (SVR) at the time of re\u2010call. We successfully reached 617 (20.5%), of whom 417 (67.6%) attended their pre\u2010treatment visit, and 397 (64.3%) commenced DAA\u2010therapy. HCV cure has been confirmed in 326 individuals, corresponding to an SVR rate of 82.1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ELIMINATE project identified 5695 people living with HCV who were \u2018lost to care\u2019 despite documented HCV viraemia. While invalid contact data were an evident barrier to HCV elimination, premature deaths among the cohort underscored the severity of untreated HCV. The implementation of a systematic HCV\u2010RNA PCR recorded\u2010based re\u2010call workflow represents an effective strategy supporting the WHO goal of HCV elimination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.16076","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T09:14:03Z","timestamp":1727774043000},"page":"3151-3163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A systematic <scp>PCR<\/scp> record\u2010based re\u2010call of <scp>HCV<\/scp>\u2010<scp>RNA<\/scp>\u2010positive people enables re\u2010linkage to care and <scp>HCV<\/scp> elimination in Austria \u2014 The <scp>ELIMINATE<\/scp> project"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-3061","authenticated-orcid":false,"given":"Lorenz","family":"Balcar","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III 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