{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:34:05Z","timestamp":1791412445474,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The impact of hepatitis C virus (HCV) eradication via direct\u2010acting antiviral (DAA) therapy on overall mortality, particularly non\u2010liver\u2010related mortality, is understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 4180 patients with chronic HCV infection who achieved sustained virological response (SVR) (HCV eradication) through DAA therapy (<jats:italic>n<\/jats:italic>\u2009=\u20092501, SVR group) or who did not receive antiviral therapy (<jats:italic>n<\/jats:italic>\u2009=\u20091679, non\u2010SVR group); 1236 from each group were chosen using propensity score matching. Causes of death and all\u2010cause mortality, including non\u2010liver\u2010related diseases, were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 4180 patients, 592 died during the follow\u2010up period. In the SVR group, the mortality rates from liver\u2010related and non\u2010liver\u2010related diseases were 16.5% and 83.5%, respectively. Compared to the non\u2010SVR group, mortality rates from liver\u2010related and non\u2010liver\u2010related diseases were 50.1% and 49.9%, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). In non\u2010cirrhotic patients, multivariable analysis revealed that SVR was an independent factor associated with both liver\u2010related (hazard ratio [HR], .251; 95% confidence interval [CI], .092\u2013.686) and non\u2010liver\u2010related (HR, .641; 95% CI, .415\u2013.990) mortalities. In cirrhotic patients, multivariable analysis revealed that SVR remained an independent factor significantly associated with liver\u2010related mortality (HR, .151; 95% CI, .081\u2013.279). In propensity score\u2010matched patients, the eradication of HCV (SVR group) decreased both liver\u2010related (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and non\u2010liver\u2010related mortality (<jats:italic>p<\/jats:italic>\u2009=\u2009.008) rates compared to persistent HCV infection (non\u2010SVR group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The elimination of HCV via DAA therapy reduced not only liver\u2010related mortality but also non\u2010liver\u2010related mortality in patients with chronic HCV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.16093","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T06:36:45Z","timestamp":1725345405000},"page":"3060-3071","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Viral eradication reduces all\u2010cause mortality in patients with chronic hepatitis C virus infection who had received direct\u2010acting antiviral therapy"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-6761","authenticated-orcid":false,"given":"Toshifumi","family":"Tada","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Society Himeji Hospital  Himeji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital  Gifu 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