{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:44:57Z","timestamp":1791398697946,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012680","name":"Universit\u00e4tsklinikum Hamburg-Eppendorf","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Portal hypertension is the main pathophysiological driver of decompensation in patients with liver cirrhosis. Epithelial cell death markers, m30 and m65, correlate with hepatic injury and predict outcomes across various stages of liver disease. We aim (i) to evaluate whether portal hypertension itself contributes to liver outcome\u2010relevant epithelial injury, and (ii) to analyse the capacity of m30\/m65 to predict outcome in patients receiving a transjugular intrahepatic portosystemic shunt (TIPS) for refractory ascites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010six patients undergoing TIPS placement for refractory ascites and 20 patients with compensated cirrhosis as controls were prospectively enrolled in this monocentric cohort study. Epithelial cell death markers were analysed pre\u2010TIPS, as well as 1\u20133 and 6\u20139\u2009months post\u2010TIPS. The capacity of baseline levels of m30\/m65 in predicting six\u2010month transplant\u2010free survival rates was analysed by multivariable Cox proportional hazards regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Levels of m30 and m65 were higher in patients with decompensated cirrhosis (pre\u2010TIPS) compared with compensated cirrhosis (controls). Following correction of portal hypertension by TIPS and recompensation, both markers decreased over time, reaching levels comparable to patients with compensated cirrhosis. On multivariable analysis, pre\u2010TIPS baseline levels of m30 and m65 were not predictive for six\u2010month survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Correction of portal hypertension via TIPS reduces levels of epithelial cell death markers, indicating that portal hypertension is a driver of outcome\u2010relevant, hepatic cell death in patients with decompensated cirrhosis. Baseline m30\/m65 values do not affect six\u2010month survival rates, which suggests that TIPS placement overcomes the unfavourable spontaneous prognosis otherwise indicated by elevated baseline m30\/65 levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.16156","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T07:08:19Z","timestamp":1731481699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Recompensation of Liver Cirrhosis by\n                    <scp>TIPS<\/scp>\n                    Reduces Epithelial Cell Death Markers, Translating Into Improved Clinical Outcome"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2781-5088","authenticated-orcid":false,"given":"Felix","family":"Piecha","sequence":"first","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg\u2010L\u00fcbeck\u2010Borstel\u2010Riems  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice\u2010Victoria","family":"Jahn","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"K\u00f6ntopf","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Koop","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Kathrin","family":"Ozga","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine, Institute of Medical Biometry and Epidemiology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirah","family":"Al\u2010Jawazneh","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Protozoa Immunology, Bernhard Nocht Institute for Tropical Medicine  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aenne","family":"Harberts","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Riedel","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Buggisch","sequence":"additional","affiliation":[{"name":"Ifi\u2010Institute for Interdisciplinary Medicine  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Benten","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Department of Gastroenterology Asklepios Hospital Harburg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-7625","authenticated-orcid":false,"given":"Peter","family":"H\u00fcbener","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar W.","family":"Lohse","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bannas","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kluwe","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.024"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100513"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.06.013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100316"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.008"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.002"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28493"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.123943"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181c0945a"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24734"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23050"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12322"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131658"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.11.050"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12337"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13117"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.2075"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29099"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29581"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1993.tb00617.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040319"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0431-x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199904)187:5<567::AID-PATH288>3.0.CO;2-J"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400669"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.04.001"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006083422303"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i38.5383"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-008-9506-y"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12091"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263989"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000912"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14240"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.08.009"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.08.010"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00520-7"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2015.00087"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32676"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32596"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-024-01423-y"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.023"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.08.025"},{"key":"e_1_2_12_44_1","first-page":"50","article-title":"Immune Dysfunction in Cirrhosis","volume":"5","author":"Noor M. T.","year":"2017","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.013"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.022"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.16095"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.03.009"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2024.03.007"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.16156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.16156","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.16156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:36:10Z","timestamp":1772973370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.16156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/liv.16156"],"URL":"https:\/\/doi.org\/10.1111\/liv.16156","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"2024-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16156"}}