{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:30:42Z","timestamp":1772991042833,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis C virus genotype 5 (HCV\u2010GT\u20105) is found mainly in South Africa. In our area in central France, the prevalence of HCV\u2010GT\u20105 is 14%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Here we evaluated sustained virological response at week 12 post\u2010treatment (SVR12) in 147 HCV\u2010GT\u20105 patients from 14 French university hospitals (2014\u20132021) treated with direct\u2010acting antivirals (DAA) in real\u2010life. Patients had mainly received sofosbuvir\/ledipasvir\u2009\u00b1\u2009ribavirin, sofosbuvir\/velpatasvir, and glecaprevir\/pibrentasvir. Overall SVR12 was 98% (144\/147). Two patients experienced relapse: one was successfully retreated with the same DAAs (sofosbuvir\/ledipasvir) plus ribavirin, and the other refused further DAA treatment. One patient with virological failure (sofosbuvir\/velpatasvir) had received a second treatment (sofosbuvir\/velpatasvir\/voxilaprevir) and progressed to cure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HCV\u2010GT\u20105 patients treated with a DAA regimen had a 99% SVR12 in intention\u2010to\u2010treat (including initial therapy and retreatment) and 100% SVR12 per protocol. Sofosbuvir\/ledipasvir, sofosbuvir\/velpatasvir, and glecaprevir\/pibrentasvir show very good efficacy in real\u2010world HCV\u2010GT\u20105 patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.16158","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T07:43:40Z","timestamp":1731397420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Direct Antivirals Can Achieve a Cure in All Patients With Chronic Hepatitis C due to Genotype 5: A French Multicentre Study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7431-2252","authenticated-orcid":false,"given":"Carine","family":"Nicolas","sequence":"first","affiliation":[{"name":"Department of Digestive and Hepatobiliary Medicine CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Domas","sequence":"additional","affiliation":[{"name":"Department of Digestive and Hepatobiliary Medicine CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9772-9591","authenticated-orcid":false,"given":"Stanislas","family":"Pol","sequence":"additional","affiliation":[{"name":"Oncology and Medical\u2010Surgical Specialities, Department of Hepatology, AP\u2010HP\/H\u00f4pital Cochin Paris\u2010Cit\u00e9 University\/INSERM U1223\u2010U1016  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0784-0710","authenticated-orcid":false,"given":"Edouard","family":"Bardou\u2010Jacquet","sequence":"additional","affiliation":[{"name":"Department of Liver Diseases, CHU Rennes Rennes University\/UMR124\/INSERM CIC1414, Institut NUMECAN  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Loustaud\u2010Ratti","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology, CHU Limoges Limoges University\/INSERM U1248  Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"M\u00e9tivier","sequence":"additional","affiliation":[{"name":"Department of Hepatology CHU Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarik","family":"Asselah","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology, AP\u2010HP\/H\u00f4pital Beaujon Paris\u2010Cit\u00e9 University\/CRI\/INSERM UMR1149  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-0323","authenticated-orcid":false,"given":"Dominique","family":"Thabut","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology, AP\u2010HP\/H\u00f4pital La Piti\u00e9 Salp\u00e9tri\u00e8re Sorbonne University\/INSERM UMR\u2010S938\/CRSA\/ICAN  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Bourli\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology, H\u00f4pital Saint\u2010Joseph Aix\u2010Marseille University\/INSERM UMR1252 IRD\/SESSTIM\/ISSPAM  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Mathurin","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology, CHU Lille Lille University\/INSERM INFINITE\u2010U1286  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Foucher","sequence":"additional","affiliation":[{"name":"Department of Hepatology CHU Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Larrey","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology, CHU Montpellier Montpellier University\/INSERM U1183  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Varaut","sequence":"additional","affiliation":[{"name":"Department of Hepatology AP\u2010HP\/H\u00f4pital Henri Mondor  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Alric","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\u2010Clinical Immunology, CHU Toulouse Toulouse III University\/RESTORE INSERM UMR\u20101301\/CNRS\u20105070\/FLAMES Team  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Bailly","sequence":"additional","affiliation":[{"name":"Department of Hepatology HCL\/Hopital Croix Rousse, INSERM U1052, Institut EVEREST  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9on","family":"Muti","sequence":"additional","affiliation":[{"name":"Department of Digestive and Hepatobiliary Medicine CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Buchard","sequence":"additional","affiliation":[{"name":"Department of Digestive and Hepatobiliary Medicine CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Abergel","sequence":"additional","affiliation":[{"name":"Department of Digestive and Hepatobiliary Medicine CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"},{"name":"Clermont\u2010Auvergne University\/CNRS\/Clermont\u2010Auvergne INP\/Institut Pascal  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"issue":"5","key":"e_1_2_9_3_1","first-page":"286","article-title":"Le Virus de L'h\u00e9patite C de G\u00e9notype 5: Un Virus Rare, Une Histoire \u00c9pid\u00e9miologique M\u00e9connue","volume":"15","author":"Henquell C.","year":"2011","journal-title":"Virologie"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.22249"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03530.x"},{"key":"e_1_2_9_6_1","unstructured":"Haute Autorit\u00e9 de Sant\u00e9 \u201cRecommandation du Coll\u00e8ge de la Has Pris en Charge de L'h\u00e9patite C par les M\u00e9dicaments Antiviraux D'action Directe (Aa) \u00c9largissement du P\u00e9rim\u00e8tre de Remboursement \u201d(2016) 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International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.16158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.16158","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.16158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:36:12Z","timestamp":1772973372000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.16158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/liv.16158"],"URL":"https:\/\/doi.org\/10.1111\/liv.16158","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"2024-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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