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Screening programs have been ongoing to reach the World Health Organisation's goal of HCV elimination by 2030, and most infected people are eligible for treatment. Given the increased cardiovascular risk in people with HCV infection and the metabolic pathways of DAAs, it is not uncommon to face the issue of drug\u2013drug interactions (DDIs) with antiplatelet or anticoagulant drugs. In the absence of clinical trials, we offer suggestions to deal with DDIs in case of treatment of patients with DAAs who are also receiving antiplatelet or anticoagulant drugs, based on the best available evidence from pharmacodynamics and pharmacokinetics studies in conjunction with clinical experience in the field of haemostasis and thrombosis.<\/jats:p>","DOI":"10.1111\/liv.16177","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T16:08:32Z","timestamp":1735574912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Drug\u2013Drug Interactions Between DAAs and Anticoagulants or Antiplatelets: A Position Paper of the Italian Anticoagulation Clinics"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0375-383X","authenticated-orcid":false,"given":"Elisabetta","family":"Tombolini","sequence":"first","affiliation":[{"name":"Emergency Medicine and Thrombosis and Haemostasis Center ASST Sette Laghi  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Squizzato","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Insubria  Varese Italy"},{"name":"Research Center on Thromboembolic Disorders and Antithrombotic Therapies, ASST Lariana University of Insubria  Como Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Marco","family":"Podda","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienza della Salute, S.C. 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