{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:57:14Z","timestamp":1787165834659,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Glecaprevir\/Pibrentasvir (GLE\/PIB) has been approved by the European Medicine Agency (EMA) and by the US Food and Drug Administration (US\u2010FDA) for the treatment of children and adolescents from 3\u2009years of age with chronic hepatitis C virus (CHC) infection. The aim of this study was to confirm the real\u2010world effectiveness and safety of GLE\/PIB in children and adolescents (3 to &lt;\u200918\u2009years old) with CHC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, multicentre study involved 11 Italian centres. Children and adolescents (from 3 to &lt;\u200918\u2009years of age) received a weight\u2010based dose (up to 300\/120\u2009mg) of GLE\/PIB once daily for 8\u2009weeks. The effectiveness endpoint was sustained virological response 12\u2009weeks after the end of treatment (SVR12). Safety was assessed by adverse events (AE) and clinical\/laboratory data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010one patients (median age 12\u2009years, interquartile range 5) were enrolled and treated between June 2020 and October 2023. Genotype distribution was as follows: 24\/61 genotype 1 (39.4%), 13\/61 genotype 2 (21.3%), 18\/61 genotype 3 (29.5%) and 6\/61 genotype 4 (9.8%). Sixty (98.4%) patients completed treatment and follow\u2010up. SVR12 was obtained by 60\/61 patients (98.4%). One patient died because of an oncological illness while on treatment. AE occurred in 13.1% of the patients, were mild and no patients prematurely stopped treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study confirmed the real\u2010life effectiveness and safety of the 8\u2010week therapy with GLE\/PIB for treatment of CHC in children and adolescents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.16180","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T04:49:30Z","timestamp":1732164570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness and Safety of Glecaprevir\/Pibrentasvir in Italian Children and Adolescents With Chronic Hepatitis C: A Real\u2010Word, Multicenter Study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3970-5000","authenticated-orcid":false,"given":"Mariangela","family":"Stinco","sequence":"first","affiliation":[{"name":"Liver Unit Meyer Children's Hospital IRCCS  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Rubino","sequence":"additional","affiliation":[{"name":"Liver Unit Meyer Children's Hospital IRCCS  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bartolini","sequence":"additional","affiliation":[{"name":"Liver Unit Meyer Children's Hospital IRCCS  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Nuti","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan 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