{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:49Z","timestamp":1787015749512,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Presence of active hepatitis C virus (HCV) infection may influence the outcome of patients treated for hepatocellular carcinoma (HCC), although this issue has never been adequately assessed in a large series of patients. The aim of this study was to evaluate whether the presence of active HCV affects the survival of patients treated for HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study assessed the outcome of 3123 anti\u2010HCV\u2010positive patients with HCC, subdivided according to the presence of active HCV infection or previous sustained virological response (SVR). Comparisons were also carried out after propensity score matching (PSM) considering demographic, clinical and oncological characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median overall survival from HCC treatment was longer in patients with SVR than in those with active HCV infection both before (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092118: 61.0\u2009months [95% confidence internal (CI): 56.5\u201365.5] vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091005: 51.0\u2009months [95% CI: 43.4\u201358.6];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and after PSM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091285: 60.0\u2009months [95% CI: 55.3\u201364.7] vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009926: 54.0\u2009months [95% CI: 46.7\u201361.3];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030). Active HCV infection was associated with a greater risk of mortality (hazard ratio: 1.22\u20131.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) independently of liver\u2010 and tumour\u2010related variables, and modality of HCC treatment. Death due to liver failure was more common in patients with active HCV infection (24.5% vs. 17.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), while non\u2010liver\u2010related causes of death were more common in patients with SVR (25.0% vs. 17.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SVR is associated with a better outcome in patients undergoing HCC treatment, thus suggesting that these patients may benefit from antiviral therapy for HCV independently of cure of HCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.16185","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T07:14:43Z","timestamp":1736320483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Absence of Viral Replication Is Associated With Improved Outcome in Anti\u2010\n                    <scp>HCV<\/scp>\n                    \u2010Positive Patients With Hepatocellular Carcinoma"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8526-837X","authenticated-orcid":false,"given":"Edoardo G.","family":"Giannini","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine University of Genoa  Genoa Italy"},{"name":"Gastroenterology Unit IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1791-4506","authenticated-orcid":false,"given":"Andrea","family":"Pasta","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4257-1058","authenticated-orcid":false,"given":"Maria Corina","family":"Plaz Torres","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine University of Genoa  Genoa Italy"},{"name":"Gastroenterology Unit IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1502-916X","authenticated-orcid":false,"given":"Giulia","family":"Pieri","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine University of Genoa  Genoa Italy"},{"name":"Gastroenterology Unit IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0946-3859","authenticated-orcid":false,"given":"Giuseppe","family":"Cabibbo","sequence":"additional","affiliation":[{"name":"Gastroenterology &amp; Hepatology Unit, Department of Health Promotion, Mother &amp; Child Care, Internal Medicine &amp; Medical Specialties, PROMISE University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9996-9385","authenticated-orcid":false,"given":"Angelo","family":"Sangiovanni","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Fondazione IRCCS Ca' Granda Ospedale maggiore Policlinico and C.R.C. \u201cA.M. &amp; A. Migliavacca Center for Liver Disease\u201d  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-1845","authenticated-orcid":false,"given":"Fabio","family":"Piscaglia","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Hepatobiliary and Immunoallergic diseases IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3842-782X","authenticated-orcid":false,"given":"Claudia","family":"Campani","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Internal Medicine and Hepatology Unit University of Florence  Florence 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