{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:18:17Z","timestamp":1779146297435,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Tissue factor\u2010expressing microvesicles (MV\u2010TF) have been found to correlate with thrombotic complications in various diseases. Simultaneously, there is expanding research regarding the effect of the coagulation cascade on liver fibrosis progression. The aim of our manuscript was to evaluate MV\u2010TF activity in patients with cirrhosis and its correlation with disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled 82 patients [11 with cirrhosis and hepatocellular cancer (Group 1), 50 with cirrhosis (Group 2) and 21 controls (Group 3)]. Extensive workup for disease staging and exclusion criteria was undertaken. Exclusion criteria included thrombophilia, history of thrombosis, recent hospitalisation, ongoing infection, alcohol dependence, cancer, haematological diseases and use of anticoagulant, antiplatelet or contraceptive drugs. Plasma tissue factor antigen concentration and MV\u2010TF activity were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MV\u2010TF showed median values of 4.03 [1.57], 3.17 [1.59] and 2.26 [1.23] pg\/mL in Groups 1, 2 and 3, respectively. There was a statistically significant difference between Groups 1 and 3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and Groups 2 and 3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), while Group 1 had higher values than Group 2 without statistical significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.088). In Group 2, the patients' Child\u2010Pugh (CP) stage was A in 56%, B in 26% and C in 18% of cases. MV\u2010TF activity significantly correlated with decompensated cirrhosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and higher CP stage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). Finally, MV\u2010TF activity significantly correlated with 12\u2010month mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MV\u2010TF activity is elevated in patients with cirrhosis, showing a significant correlation with disease severity. MV\u2010TF may play a role in the procoagulant imbalance of liver cirrhosis and their contribution in disease progression should be studied further.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.16192","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T07:05:32Z","timestamp":1732691132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Microvesicle Tissue Factor Procoagulant Activity Is Elevated and Correlated With Disease Severity in Patients With Cirrhosis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7117-0547","authenticated-orcid":false,"given":"Adonis A.","family":"Protopapas","sequence":"first","affiliation":[{"name":"First Propaedeutic Department of Internal Medicine Aristotle University of Thessaloniki, AHEPA University Hospital  Thessaloniki Greece"},{"name":"Fourth Department of Internal Medicine Aristotle University of Thessaloniki, Hippokration General Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Takardaki","sequence":"additional","affiliation":[{"name":"Department of Microbiology Aristotle University of Thessaloniki, AHEPA University Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nefeli","family":"Protopapa","sequence":"additional","affiliation":[{"name":"First Propaedeutic Department of Internal Medicine Aristotle University of Thessaloniki, AHEPA University Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-0154","authenticated-orcid":false,"given":"Ioanna","family":"Papagiouvanni","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine Aristotle University of Thessaloniki, Hippokration General Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas N.","family":"Protopapas","sequence":"additional","affiliation":[{"name":"First Propaedeutic Department of Internal Medicine Aristotle University of Thessaloniki, AHEPA University Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lemonia","family":"Skoura","sequence":"additional","affiliation":[{"name":"Department of Microbiology Aristotle University of Thessaloniki, AHEPA University Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Savopoulos","sequence":"additional","affiliation":[{"name":"First Propaedeutic Department of Internal Medicine Aristotle University of Thessaloniki, AHEPA University Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Goulis","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine Aristotle University of Thessaloniki, Hippokration General Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2021.100222"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.89a.21018"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15239"},{"issue":"1","key":"e_1_2_12_5_1","first-page":"1","article-title":"Anticoagulation in Patients With Liver Cirrhosis: Friend or Foe?","volume":"2023","author":"Protopapas A. 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