{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:03:45Z","timestamp":1793804625765,"version":"4.6.1"},"reference-count":148,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic hepatitis B virus (HBV) infection is a common but underdiagnosed and undertreated health condition and is the leading cause of hepatocellular carcinoma (HCC) worldwide. HBV (rated a Grade 1 carcinogen by the International Agency for Research on Cancer) drives the transformation of hepatocytes in multiple ways by inducing viral DNA integrations, genetic dysregulation, chromosomal translocations, chronic inflammation, and oncogenic pathways facilitated by some HBV proteins. Importantly, these mechanisms are active throughout all phases of HBV infection. Nevertheless, most clinical guidelines for antiviral therapy recommend treatment based on a complex combination of HBV DNA levels, transaminasemia, liver histology, and demographic factors, rather than prompt treatment for all people with infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine whether current antiviral treatment frameworks address the impacts of chronic HBV infection, particularly in preventing cancer development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We reviewed recent data demonstrating that antiviral therapy can inhibit pro\u2010oncogenic factors acting throughout a chronic HBV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We conducted an extensive review of Hepatitis B virology data and correlating clinical outcomes based on these findings we propose simplifying and expanding treatment initiation to reduce the incidence of new infections, prevent progression of liver disease, and lower the risk of hepatocellular carcinoma. Additionally, we draw insights from other blood\u2010borne pathogens, emphasizing the benefits of antiviral treatment in preventing transmission, reducing stigma, and reframing treatment as a strategy for cancer prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Incorporating these practice changes into treatment is likely to reduce the overall burden of chronic HBV infections and HCC. Through this, we may better achieve the World Health Organization's goal of eliminating viral hepatitis as a public health threat and minimise its impact on people's lives.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.16202","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T10:55:18Z","timestamp":1735124118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["<scp>HBV<\/scp>\u2010Induced Carcinogenesis: Mechanisms, Correlation With Viral Suppression, and Implications for Treatment"],"prefix":"10.1111","volume":"45","author":[{"given":"Thomas","family":"Tu","sequence":"first","affiliation":[{"name":"Storr Liver Centre, Westmead Clinical School, Centre for Infectious Diseases and Microbiology and Westmead Institute for Medical Research The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0977-6553","authenticated-orcid":false,"given":"Thomas J.","family":"McQuaid","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc.  Provincetown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira M.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Hepatitis B","author":"World Health Organization","year":"2020"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30831"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6701a1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.30385"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.04.030"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_12_9_1","unstructured":"World Health Organization \u201cGlobal Progress Report on HIV Viral Hepatitis and Sexually Transmitted Infections 2021: Accountability for the Global Health Sector Strategies 2016\u20132021: Actions for Impact \u201d(2021)."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1676806"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.042"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12773"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323153"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100388"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.07.012"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.07.022"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.075"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1859"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.79"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13030368"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100449"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100195"},{"issue":"5","key":"e_1_2_12_23_1","first-page":"769","article-title":"Guidelines for Prevention and Treatment of Chronic Hepatitis B","volume":"9","author":"Wang G.","year":"2021","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.07.036"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9675-4"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29537"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.257"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004433"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13774"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13253"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314904"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15499"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i11.1101"},{"issue":"1","key":"e_1_2_12_34_1","first-page":"133","article-title":"Prognostic Factors and Clinical Characteristics of Chronic Hepatitis B With or Without Nucleos(t)ide Analogues Therapy: A Retrospective Study","volume":"52","author":"Li M.","year":"2022","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300937"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.8.1269"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158903"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v11.i1.1"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S384438"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16091361"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.015"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.026"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-019-1183-z"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00452-3"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201800182"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00786-10"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02440-14"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.3.2026-2030.1994"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-015-0293-5"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02196-09"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/351317a0"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.08.010"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8209"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30553"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205096"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-1107-9"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040741"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10079-1"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.12.5449-5455.2003"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2003.11.025"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231912015"},{"issue":"9","key":"e_1_2_12_62_1","first-page":"2210","article-title":"Hepatitis B x (HBx) as a Component of a Functional Cure for Chronic Hepatitis B","volume":"10","author":"Feitelson M. A.","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100514"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12992"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-07048-5"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.2064"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.10.033"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6331"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198110293051807"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403925101"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes9070365"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220376"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323153"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02007-17"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-021-00245-1"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00299-21"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323300"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26805-8"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.314351.118"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13102454"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2295"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31231"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao0535"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i20.6236"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.014"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.05.032"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13039-021-00553-2"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0872-9"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/v9040075"},{"issue":"2","key":"e_1_2_12_90_1","first-page":"314","article-title":"Reduction in Intrahepatic cccDNA and Integration of HBV in Chronic Hepatitis B Patients With a Functional Cure","volume":"11","author":"Gan W.","year":"2023","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac383"},{"key":"e_1_2_12_92_1","unstructured":"Y.\u2010C.Hsu V.Suri Z.Jiang et\u00a0al. \u201cTenofovir Disoproxil Fumarate Treatment Reduces the Number of Transcriptionally Active Viral Integrations in Chronically Infected HBV Patients \u201d Paper Presented at: AASLD (2020)."},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14133274"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005350200149"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.2174\/2213988501812010009"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1133308"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S377768"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.52979"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-018-0048-z"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29372"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1495"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.03.008"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.03.019"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1989311"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.02.009"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i2.109"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120020"},{"issue":"3","key":"e_1_2_12_108_1","first-page":"2221","article-title":"Reduction Therapy of Alanine Aminotransferase Levels Prevent HCC Development in Patients With HCV\u2010Associated Cirrhosis","volume":"26","author":"Rino Y.","year":"2006","journal-title":"Anticancer Research"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807093390201"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066422"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37058"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033364"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26301"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26180"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.10.014"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.04.037"},{"issue":"2","key":"e_1_2_12_117_1","article-title":"HIV Infection and the Risk of Hepatocellular Carcinoma in Patients With Hepatitis B Virus (HBV) Co\u2010Infection: A Propensity Score\u2010Matched Cohort Study","volume":"6","author":"Liu G.","year":"2019","journal-title":"Open Forum Infectious Diseases"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29913"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.064"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.665201"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04014.x"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29487"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533033819846632"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13185"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000459"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac385"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2023.06.001"},{"issue":"6","key":"e_1_2_12_128_1","first-page":"1425","article-title":"Guidelines for the Prevention and Treatment of Chronic Hepatitis B (Version 2022)","volume":"11","author":"You H.","year":"2023","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_12_129_1","volume-title":"Guidelines for the Prevention, Diagnosis, Care and Treatment for People With Chronic Hepatitis B Infection","author":"Organization WH","year":"2024"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.08.022"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1177\/135965350601100704"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14050900"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-016-0557-9"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.02.016"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31112"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13020180"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.286"},{"key":"e_1_2_12_138_1","unstructured":"N.Chow D. K.\u2010H.Wong L. Y.Mak et\u00a0al. \u201cLong Term Nucleos(t)ide Analogue Therapy Reduced the Extentof HBV DNA Integration in Chronic Hepatitis B Patients \u201d Paper Presented at: Hepatology (2020)."},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12050515"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.2952"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v13.i6.509"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13843"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2023.100738"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000299"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061922"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1177\/0017896914523276"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i5.227"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.2.191"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-015-0850-2"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.16202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T07:14:34Z","timestamp":1739258074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.16202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,25]]},"references-count":148,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/liv.16202"],"URL":"https:\/\/doi.org\/10.1111\/liv.16202","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,25]]},"assertion":[{"value":"2024-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16202"}}