{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:26:57Z","timestamp":1780702017143,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Primary sclerosing cholangitis (PSC) is among the most common indications for liver transplantation in the Nordic countries and with an increasing trend in Europe and North America. Due to post\u2010transplant complications and high prevalence of disease recurrence this group is at risk of requiring retransplantation (re\u2010LTX). Results from re\u2010LTX for PSC are not extensively studied and there is a lack of knowledge regarding prognosis after re\u2010LTX in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Graft and patient survival after re\u2010LTX for patients with PSC and a comparable comparison group from the Nordic liver transplant registry were analysed. One\u2010hundred and eighty\u2010five patients with PSC and 208 patients in the comparison group were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The graft and patient survival were better for patients with PSC compared to the comparison group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Re\u2010LTX for recurrence of PSC (rPSC) compared to other aetiologies had similar and better outcomes for graft and patient survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.093 and <jats:italic>p<\/jats:italic>\u2009=\u20090.023, respectively). Moreover, re\u2010LTX for rPSC compared to the comparison group had a lower 30\u2010day and 5\u2010year mortality (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>p<\/jats:italic>\u2009=\u20090.041, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outcomes after retransplantation for PSC were similar or better compared to the comparison group. Retransplantation represents a treatment option with the potential for excellent outcomes in patients with PSC and should be considered in transplanted PSC patients with graft failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.16214","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T11:45:27Z","timestamp":1734349527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcome of Liver Retransplantation in Patients With Primary Sclerosing Cholangitis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-2238","authenticated-orcid":false,"given":"Antonio","family":"Molinaro","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Wallenberg Laboratory University of Gothenburg  Gothenburg Sweden"},{"name":"Norwegian PSC Research Center, Division of Surgery and Specialized Medicine Oslo University Hospital  Oslo Norway"},{"name":"Research Institute of Internal Medicine, Division of Surgery and Specialized Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise Katrine","family":"Enges\u00e6ter","sequence":"additional","affiliation":[{"name":"Norwegian PSC Research Center, Division of Surgery and Specialized Medicine Oslo University Hospital  Oslo Norway"},{"name":"Research Institute of Internal Medicine, Division of Surgery and Specialized Medicine Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Section of Gastroenterology, Department of Transplantation Medicine, Division of Surgery and Specialized Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7727-8113","authenticated-orcid":false,"given":"Carl","family":"Jorns","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Nordin","sequence":"additional","affiliation":[{"name":"Department of Transplantation and Liver Surgery University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology and Liver Transplantation, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l\u2010Dag","family":"Line","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Section of Transplantation Surgery, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virge","family":"Pall","sequence":"additional","affiliation":[{"name":"Transplantation Centre Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010G\u00f6ran","family":"Ericzon","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet Karolinska University Hospital  Stockholm 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Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-6878","authenticated-orcid":false,"given":"Espen","family":"Melum","sequence":"additional","affiliation":[{"name":"Norwegian PSC Research Center, Division of Surgery and Specialized Medicine Oslo University Hospital  Oslo Norway"},{"name":"Research Institute of Internal Medicine, Division of Surgery and Specialized Medicine Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Section of Gastroenterology, Department of Transplantation Medicine, Division of Surgery and Specialized Medicine Oslo University Hospital  Oslo Norway"},{"name":"Hybrid Technology Hub\u2010Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine University of Oslo  Oslo 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