{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:33:56Z","timestamp":1790775236632,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST111\u20102314\u2010B\u2010075\u2010056"],"award-info":[{"award-number":["MOST111\u20102314\u2010B\u2010075\u2010056"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC112\u20102314\u2010B\u2010075\u2010043\u2010MY2"],"award-info":[{"award-number":["NSTC112\u20102314\u2010B\u2010075\u2010043\u2010MY2"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC113\u20102314\u2010B\u2010075\u2010054\u2010MY3"],"award-info":[{"award-number":["NSTC113\u20102314\u2010B\u2010075\u2010054\u2010MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V112C\u2010039"],"award-info":[{"award-number":["V112C\u2010039"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Body composition is an objective assessment reflecting nutritional status and is highly gender different. Surgical resection, the standard treatment for early\u2010stage hepatocellular carcinoma (HCC), is an energy\u2010consuming major operation that would affect body composition. However, the impacts of body composition on the post\u2010operative prognosis of HCC are still uncertain. In this study, we aimed to investigate surgery\u2010related changes in body composition and the impacts on clinical outcomes of HCC after surgical resection distinguished by gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>From January 2013 to December 2018, 401 consecutive patients who received surgical resection for HCC in Taipei Veterans General Hospital were retrospectively reviewed. Cross areas of adipose and muscle mass were measured at L3 vertebral level from peri\u2010operative computed tomography by Slice\u2010O\u2010matic software; body composition indices were thus calculated. Factors associated with survivals were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Body composition indices did not change significantly after surgical resection of HCC in both males and females. Higher pre\u2010operative intramuscular adipose tissue index (IMATI) (hazard ratio [HR]: 2.059,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and lower ratio of subcutaneous to visceral adipose tissue index (SATI\/VATI) (HR: 1.681,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028) were independent predictors of worse overall survival (OS) in male patients. In females, higher pre\u2010operative IMATI (HR: 3.053,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) was the only body composition\u2010related factor predicting OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Surgical resection contributed minor changes in body composition in patients with early HCC. Myosteatosis and subcutaneous to visceral fat ratio were survival predictors in male patients, but myosteatosis was the only body composition\u2010predictor of survival in females.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.16237","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T03:15:01Z","timestamp":1736478901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gender Different Impacts of Muscle Mass and Adipose Tissue on Patients With Hepatocellular Carcinoma Undergoing Surgical Resection"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7492-2484","authenticated-orcid":false,"given":"Pei\u2010Chang","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Yi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Gastroenterology and Hepatology West Garden Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3211-9426","authenticated-orcid":false,"given":"Chun\u2010Ting","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9879-5318","authenticated-orcid":false,"given":"Kuo\u2010Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Division of Gastroenterology, Department of Internal Medicine Taipei City Hospital Yang\u2010Ming Branch  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0137-2300","authenticated-orcid":false,"given":"Gar\u2010Yang","family":"Chau","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Division of General Surgery, Department of Surgery Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5241-5425","authenticated-orcid":false,"given":"Yi\u2010Hsiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Clinical Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Healthcare and Services Center Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-521X","authenticated-orcid":false,"given":"Teh\u2010Ia","family":"Huo","sequence":"additional","affiliation":[{"name":"Division of Basic Research, Department of Medical Research Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Pharmacology, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4886-0718","authenticated-orcid":false,"given":"Ming\u2010Chih","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9645-3044","authenticated-orcid":false,"given":"Jaw\u2010Ching","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-7004","authenticated-orcid":false,"given":"Chien\u2010Wei","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Clinical Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Division of General Medicine, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07580-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.4334"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i8.1243"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.236"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2017.93.5.252"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.302"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-021-00507-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2023.111025"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2012.01035.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2016.00168"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-0964-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9101054"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75198-z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081206"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.02.031"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28912"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.07.008"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13466"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.07.029"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12144783"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29086"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14175"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.200410135"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12780"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488779"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2016.016832"},{"key":"e_1_2_10_31_1","first-page":"509","article-title":"Can Obesity\u2010Induced Inflammation in Skeletal Muscle and Intramuscular Adipose Tissue Accurately Detect Liver Fibrosis?","volume":"18","author":"Chasapi A.","year":"2018","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23046"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3287"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.04.015"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S167417"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29578"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.09.001"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29971"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-022-01733-9"},{"issue":"107","key":"e_1_2_10_40_1","first-page":"25","article-title":"Postmenopausal Hormone Replacement Therapy Modifies Skeletal Muscle Composition and Function: A Study With Monozygotic Twin Pairs","volume":"2009","author":"Ronkainen P. H.","year":"1985","journal-title":"Journal of Applied Physiology"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.05.020"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16050952"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2023-0025"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030720"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16020454"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31184-9"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.16237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T04:04:20Z","timestamp":1744171460000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.16237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/liv.16237"],"URL":"https:\/\/doi.org\/10.1111\/liv.16237","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,10]]},"assertion":[{"value":"2024-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16237"}}