{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:00:09Z","timestamp":1787619609624,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The Baveno VII consensus recommends spleen stiffness measurement (SSM) for the detection of clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic liver disease (cACLD). We aimed to evaluate the performance of SSM\u2010based algorithms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive cACLD individuals who underwent hepatic venous pressure gradient measurement, liver stiffness measurement (LSM), and SSM measured with the dedicated 100\u2010Hz probe by vibration\u2010controlled transient elastography were prospectively enrolled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From July 2021 to August 2024, a total of 395 patients were screened, and 185 cACLD cases were enrolled, of which 101 patients had CSPH. An SSM\u2009&gt;\u200950\u2009kPa demonstrated a positive predictive value (PPV) of 98.0% and a specificity of 98.8% for ruling in CSPH, correctly identifying 47.5% (48\/101) of CSPH cases. Sensitivity analysis revealed that in 60 patients with aetiology removal or suppression, SSM\u2009&gt;\u200950\u2009kPa achieved both a PPV and specificity of 100%. Among the 125 patients with ongoing aetiologies, the PPV and specificity were 96.4% and 98.3%, respectively. Across HBV (with or without viral suppression) and non\u2010HBV subgroups, the PPV and specificity consistently exceeded 90%. In decision curve analysis, SSM\u2009&gt;\u200950\u2009kPa provided the highest net benefit compared with other elastography\u2010based algorithms when threshold probabilities exceeded 0.8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We prospectively validated that SSM\u2009&gt;\u200950\u2009kPa, measured using the spleen\u2010dedicated probe, is sufficient for identifying CSPH in individuals with cACLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>NCT04820166<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.16241","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T08:59:10Z","timestamp":1742374750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of Clinically Significant Portal Hypertension in\n                    <scp>cACLD<\/scp>\n                    Individuals With Spleen Stiffness Measurement"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6871-075X","authenticated-orcid":false,"given":"Xiaofeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"Department of Hepatology, Zengcheng Branch, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Liang","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"Department of Hepatology, Zengcheng Branch, Nanfang Hospital Southern Medical University  Guangzhou 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Diseases, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"Department of Hepatology, Zengcheng Branch, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junying","family":"Li","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"Department of Hepatology, Zengcheng Branch, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Wang","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Department of Infectious Diseases, 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