{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:24:44Z","timestamp":1784615084276,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Short courses of intravenous (iv) methylprednisolone (MP) can cause drug induced liver injury (DILI). The aim of this study was to assess the clinical features and HLA associations of MP\u2010related DILI enrolled in the US DILI Network (DILIN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>DILIN cases with MP as a suspected drug were reviewed. DILIN causality scoring was assigned on a 5\u2010point scale (definite, highly likely, probable, possible, unlikely). All cases with MP causality scores of definite, highly likely or probable were analysed. HLA data from direct sequencing were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven cases of definite, highly likely, or probable MP DILI were identified. The median age was 48\u2009years; 73% were female; median latency to onset was 30\u2009days; 55% were jaundiced; and all had hepatocellular injury with one patient requiring transplantation. Nine of the 11 cases were in patients with multiple sclerosis (MS). Liver biopsies in 7 cases revealed mild acute hepatitis with\/without cholestasis. HLA data demonstrated that <jats:italic>HLA\u2010DRB1*15<\/jats:italic>:<jats:italic>01<\/jats:italic>, the primary HLA class II allele associated with MS was over\u2010represented. <jats:italic>HLA\u2010DQB1*06:02\u2010HLA\u2010DQA1*01:02<\/jats:italic> which is haplotypic with the <jats:italic>HLA\u2010DRB1<\/jats:italic>*<jats:italic>15<\/jats:italic> haplotype was more common in the MP DILI cases compared to other DILI controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) and to DILI controls exposed to MP (<jats:italic>p<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MP DILI is characterised by hepatocellular injury, short latency and generally rapid recovery. There was no independent HLA haplotype associated with MP DILI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.16242","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T13:11:19Z","timestamp":1736773879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Liver Injury due to Intravenous Methylprednisolone in the Drug\u2010Induced Liver Injury Network"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1384-2349","authenticated-orcid":false,"given":"Jawad","family":"Ahmad","sequence":"first","affiliation":[{"name":"Recanati\u2010Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ju","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Phillips","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Dellinger","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Food and Drug Administration  Silver Spring MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naga","family":"Chalasani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9161-5892","authenticated-orcid":false,"given":"Robert J.","family":"Fontana","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-4453","authenticated-orcid":false,"given":"David E.","family":"Kleiner","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Intramural Division National Cancer Institute, National Institutes of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiman X.","family":"Barnhart","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay H.","family":"Hoofnagle","sequence":"additional","affiliation":[{"name":"Liver Disease Research Branch, Division of Digestive Diseases and Nutrition National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Drug\u2010Induced Liver Injury Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2011\/011856s103s104lbl.pdf accessed June 30 2024."},{"key":"e_1_2_13_3_1","unstructured":"https:\/\/www.nice.org.uk\/guidance\/ng220 accessed June 30 2024."},{"key":"e_1_2_13_4_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.968","article-title":"Liver Injury After Pulsed Methylprednisolone Therapy in Multiple Sclerosis Patients","volume":"8","author":"Nociti 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