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The objective of this review is to address the current knowledge of molecular mechanisms involved in HNF4\u03b1 regulation in multiple aspects of liver disease pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on available literature, this review summarises the current state of knowledge onthe mechanism of HNF4\u03b1 dysregulation, and the role of HNF4\u03b1 activity inregulating early to advanced stages of various liver diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with deranged HNF4\u03b1 expression are at higher risk for the development of liver diseases such as viral hepatitis, alcoholic\/nonalcoholic fatty liver disease, hepatocellular carcinoma, and haematological disorders such as coagulopathy and bleeding disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>HNF4\u03b1 interactions with nuclear receptors and target genes promote liver disease pathology by regulating various metabolic pathways. The strong correlation between deranged HNF4\u03b1 expression and the severity of liver diseases suggests that targeting HNF4\u03b1 expression can offer potential therapeutic strategy in the prevention of liver disease pathology and haemostatic disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.16245","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T13:20:59Z","timestamp":1747660859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hepatocyte Nuclear Factor 4 Alpha: A Key Regulator of Liver Disease Pathology and Haemostatic Disorders"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0119-1844","authenticated-orcid":false,"given":"Subhadip","family":"Choudhuri","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology University of Texas Medical Branch (UTMB)  Galveston Texas USA"},{"name":"Institute for Human 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