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Lately, we found methyl tert\u2010butyl ether (MTBE), a new environmental pollutant, could increase NAFLD risk in American adults, which still needs more population epidemiological studies to verify, and its pathogenic mechanism is not yet clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study among petrol station workers, diagnosed their MAFLD according to internationally recognised diagnostic criteria, assessed the potential association of MTBE exposure with MAFLD risk, and explored the miR\u201018a\u20105p\/PXR\/SREBP2 pathway as possible pathogenic mechanisms in male Wistar rats and HepaRG cells treated with MTBE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blood MTBE levels were found to be significantly correlated with an increased risk of MAFLD, and MAFLD risk increased by 24.3% for every 0.1\u2009\u03bcg\/L increase in blood MTBE. Consistently, we found that MTBE exposure could induce MAFLD in rats and HepaRG cells, and activate pregnane X receptor (PXR) by inhibiting miR\u201018a\u20105p to upregulate the expression of sterol regulatory element\u2010binding protein 2 (SREBP2) and its nuclear translocation, thereby upregulating the expression of its downstream target genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrated that MTBE exposure might be a significant risk factor for MAFLD, and MTBE could promote liver cholesterol synthesis and lipid deposition by activating the miRNA\u201018a\u20105p\/PXR\/SREBP2 pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.16246","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T10:46:30Z","timestamp":1737110790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>miR<\/scp>\u201018a\u20105p\/<scp>PXR<\/scp>\/<scp>SREBP2<\/scp> Was Involved in <scp>MAFLD<\/scp> Associated With Methyl Tert\u2010Butyl Ether Among Petrol Station Workers"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4890-4083","authenticated-orcid":false,"given":"Hanyun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Occupational Health and Environmental Health School of Public Health, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8102-6744","authenticated-orcid":false,"given":"Mingxiao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environmental Health School of Public Health, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengtao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environmental Health School of Public Health, Capital Medical University  Beijing China"},{"name":"Occupational Disease Prevention and Control Hospital of Huaibei Mining Co. 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