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While liver test abnormalities are rather common in patients treated with kinase inhibitors or immunotherapy, events of severe hepatotoxicity in these patients are rare in comparison with those associated with chemotherapeutics. The underlying mechanisms and risk factors for severe hepatotoxicity with novel oncology therapies are not well understood, complicating the drug\u2010induced liver injury (DILI) risk assessment in the preclinical and clinical phases of drug development. The epidemiological and clinical characteristics, as well as mechanisms of liver toxicity, are described here to the current state of knowledge. Tools to study and assess the risk of DILI during drug development are concisely summarised, focusing on caveats thereof for novel oncology treatments. Emerging tools to optimise safety assessments and gather additional mechanistic insights into DILI are introduced. 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Trends in patient safety\u2010centred drug development programmes and regulatory approval processes must continually be revisited and streamlined via obtaining an overall greater understanding of DILI and the tools available to assess mechanisms of injury, frequency, severity and prognosis.<\/jats:p>","DOI":"10.1111\/liv.70002","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T07:34:16Z","timestamp":1737704056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Drug\u2010Induced Liver Injury Associated With Emerging Cancer Therapies"],"prefix":"10.1111","volume":"45","author":[{"given":"Piotr","family":"Chodup","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Toxicology University Hospital Z\u00fcrich, University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia L.","family":"Samodelov","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Toxicology University Hospital Z\u00fcrich, University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0209-5600","authenticated-orcid":false,"given":"Michele","family":"Visentin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Toxicology University Hospital Z\u00fcrich, University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0757-4408","authenticated-orcid":false,"given":"Gerd A.","family":"Kullak\u2010Ublick","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Toxicology University Hospital Z\u00fcrich, University of Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Mechanistic Safety, Patient Safety &amp; 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