{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:46:23Z","timestamp":1793745983491,"version":"4.6.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013362","name":"Swiss Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The prevalence of hepatitis delta virus (HDV) infection among persons living with hepatitis B virus (HBV) and its impact on liver\u2010related complications in West Africa are ill\u2010defined. Wetested a large urban HBV cohort in Senegal for the presence of HDV\/HBV co\u2010infection and evaluated its association with liver fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included persons with positive hepatitis B surface antigen (HBsAg) enrolled in the SEN\u2010B cohort since 2019. Anti\u2010HDV antibodies (HDVAb) were tested using the Anti\u2010HD Diasorin LiaisonXL test, HDV RNA was measured with RT\u2010qPCR and genotyping was determined through sequencing. We used multivariable logistic regression to evaluate the association between HDVAb positivity and liver fibrosis, defined as a liver stiffness measurement &gt;\u20097.0\u2009kPa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analysed 914 individuals with a median age of 32\u2009years (interquartile range [IQR] 26\u201341), of whom 487 (53.3%) were men and 117 (12.8%) had HIV co\u2010infection. Thirteen participants (1.4%, 95% CI 0.8\u20132.4) had a positive HDVAb test, of whom 8\/13 (61.5%) showed detectable HDV RNA. HDV genotype 5 was found in 75.0% of cases. In multivariable analyses, HDVAb positivity (aOR 11.7, 95% CI 3.1\u201345.7), male sex (aOR 5.4, 95% CI 3.1\u201310.3), ALT &gt;\u200940\u2009IU\/L (aOR 4.4, 95% CI 2.4\u20138.2) and HBeAg positivity (aOR 4.6, 95% CI 1.8\u201311.9) were independently associated with liver fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of HDV infection was low in persons living with HBV in Dakar, but those affected had a very high risk of presenting with liver cirrhosis. Efforts to improve HDV screening and management are urgently needed in Senegal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70026","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T03:04:36Z","timestamp":1739934276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hepatitis Delta and Liver Disease Among People Living With Hepatitis B With or Without\n                    <scp>HIV<\/scp>\n                    Co\u2010Infection in Senegal"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6639-5648","authenticated-orcid":false,"given":"Bruce Shinga","family":"Wembulua","sequence":"first","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales Fann University Hospital  Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred\u00e9ric","family":"Le Gal","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence des H\u00e9patites Virales B, C et Delta, Laboratoire de Microbiologie clinique, H\u00f4pital Avicenne, Assistance Publique H\u00f4pitaux de Paris Sorbonne Universit\u00e9, Paris Cit\u00e9  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ousseynou","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Recherche et Formation Clinique \u00e0 la Prise en Charge de Fann Fann University Hospital  Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Sandrine","family":"Pandi","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Recherche et Formation Clinique \u00e0 la Prise en Charge de Fann Fann University Hospital  Dakar Senegal"},{"name":"Doctoral School of Life Sciences, Health, and Environment Cheikh Anta Diop University of Dakar  Dakar 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