{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:23:22Z","timestamp":1793413402808,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The impact of bulevirtide in patients awaiting liver transplantation (LT) for decompensated liver disease and\/or hepatocellular carcinoma (HCC) is unclear. We assessed clinical, virological, and biochemical responses to bulevirtide in patients with chronic hepatitis delta virus (HDV) awaiting LT and compared outcomes with a cohort of similar untreated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive HDV\u2010infected patients waiting for LT since bulevirtide approval were included. Patients receiving 2\u2009mg of bulevirtide daily had clinical, biological, and virological data collected at baseline, Week 24, Week 48, at LT, and post\u2010LT. Patients not receiving bulevirtide had data collected at baseline, LT, and post\u2010LT for comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010one patients from nine LT centers were included. In the bulevirtide group (20 patients; mean age 52.8\u2009\u00b1\u20099.98\u2009years; 75% male), 65%, 10% and 25% were Child\u2010Pugh A, B and C, respectively. Fifteen completed 48\u2009weeks of therapy. At 48\u2009weeks, median HDV RNA decreased by 2.56 log IU\/mL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Virological and biochemical responses were obtained in 73.3% and 66.6% of patients. Twelve patients (60%) underwent LT. No serious adverse events occurred. Bulevirtide improved liver function, enabling one (7.1%) HCC patient to undergo chemoembolization while on the WL and leading to delisting of three (15%) other patients. In untreated patients (mean age 42.9\u2009\u00b1\u20097.9\u2009years; 76.2% Child\u2010Pugh C), none were delisted. Three\u2010month transplant\u2010free survival was 76.9% in the bulevirtide group versus 36.7% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) in the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bulevirtide demonstrates safety and efficacy in HDV\u2010infected patients listed on the LT waiting list and may potentially improve pre\u2010transplant outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70033","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T07:50:09Z","timestamp":1739778609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Bulevirtide in Chronic Hepatitis D Patients Awaiting Liver Transplantation Results From a French Multicentric Retrospective Study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5569-7285","authenticated-orcid":false,"given":"Magdalena","family":"Meszaros","sequence":"first","affiliation":[{"name":"Liver Transplantation and Hepatogastroenterology Unit CHU Montpellier, CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010No\u00eblle","family":"Hilleret","sequence":"additional","affiliation":[{"name":"Hepato\u2010Gastroenterology Unit CHU Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-5396","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Dumortier","sequence":"additional","affiliation":[{"name":"Digestive Diseases Federation Edouard Herriot Hospital, Hospices Civils de Lyon, Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"D'Alteroche","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit CHU Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Abergel","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit CHU Estaing Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Latournerie","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit CHU Dijon  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Antonini","sequence":"additional","affiliation":[{"name":"Hepatology Unit H\u00f4pital de la Croix\u2010Rousse  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Conti","sequence":"additional","affiliation":[{"name":"Hepatology Unit Piti\u00e9 Salp\u00eatri\u00e8re, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Borentain","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit CHU Timone  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Dharancy","sequence":"additional","affiliation":[{"name":"Hepatology Unit Claude Huriez Hospital, CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5269-8373","authenticated-orcid":false,"given":"Georges\u2010Philippe","family":"Pageaux","sequence":"additional","affiliation":[{"name":"Liver Transplantation and Hepatogastroenterology Unit CHU Montpellier, CHU Montpellier  Montpellier France"},{"name":"University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRGASTRO.2009.205"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA0912696"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12788"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz633"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2020.04.008"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.10.043"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2016.04.013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.016"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(22)00318\u20108"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.05.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/S40265\u2010020\u201001400\u20101"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004138"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.10.006"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25419"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2021.12.022"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.025"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.27210"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50315"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.07.016"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000847"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEPR.2023.100686"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101070"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.027"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP4.1633"}],"container-title":["Liver 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