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Country\u2010specific EQ\u20105D tariffs were developed to account for this but are not always stated in the literature. We aim to assess the reporting of EQ\u20105D in the literature and the impact of applying country\u2010specific tariffs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed literature\u2010reported EQ\u20105D utilities for patients with metabolic dysfunction\u2010associated steatohepatitis versus real\u2010world EQ\u20105D utilities from the Adelphi Real World Non\u2010alcoholic steatohepatitis Disease Specific Programme (DSP), a cross\u2010sectional survey in France, Germany, Italy, Spain, the United Kingdom and the United States. Matching\u2010adjusted indirect comparison analysis balanced DSP data with literature studies by age, sex, comorbidities and fibrosis stage. DSP utility scores generated using national tariffs were compared with literature utilities using weighted t tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies with varying recruitment criteria, patient demographics and clinical characteristics were identified. Country\u2010specific tariffs were not used or not reported. EQ\u20105D utilities varied, reflecting geographic, clinical and demographic characteristics. The comparison of literature and matched utilities derived using DSP data and five national tariffs revealed\u2009\u2265\u2009two comparisons for each study with a difference not exceeding the minimal clinically important difference versus the matched DSP value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Literature\u2010reported EQ\u20105D utilities vary considerably depending on study methodology and country\u2010specific EQ\u20105D tariff, and even if stated may not always use the most appropriate tariff. This suggests a need for consistent use of country\u2010specific tariffs and sensitivity analyses confirming results and conclusions that include EQ\u20105D\u2010based utility measurement to inform decision\u2010making by health authorities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.70043","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T09:54:38Z","timestamp":1744019678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Choice of Tariff When Calculating Clinically Meaningful <scp>EQ<\/scp>\u2010<scp>5D<\/scp> Scores in Metabolic Dysfunction\u2010Associated Steatohepatitis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-1021","authenticated-orcid":false,"given":"James","family":"Piercy","sequence":"first","affiliation":[{"name":"Adelphi Real World  Bollington 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