{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:07:40Z","timestamp":1791230860968,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Use of proton pump inhibitors (PPIs) may have adverse effects in patients with alcohol\u2010related cirrhosis (ALD cirrhosis), but PPIs continue to be used by many patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to describe the prevalence and incidence of PPI use from filled prescriptions among patients with ALD cirrhosis and to identify predictors of PPI initiation after ALD cirrhosis diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used Danish nationwide healthcare registries to investigate PPI use among patients diagnosed with ALD cirrhosis from 1997 to 2022. We used multivariable Cox regression to identify predictors of PPI initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 41\u2009263 patients diagnosed with ALD cirrhosis in 1997\u20132022. In this cohort, the prevalence of PPI use rose to 40% in 2016 and plateaued at this level through 2022. Considering time since diagnosis, 26% were using PPI at the diagnosis of ALD cirrhosis, and the prevalence peaked at 38% 3\u2009months later. Among PPI users, 79% used more than 30 defined daily doses per year on average during the follow\u2010up. Patients older than 50\u2009years were more likely than younger patients to initiate PPI treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of PPIs continues to be prevalent among patients with ALD cirrhosis, with 40% of all patients using PPIs in 2022. Within the first 3\u2009months after diagnosis, 38% of all patients were using PPIs. Our results provide essential background information for future RCTs on the risks and benefits of prescribing or deprescribing PPIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70061","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T08:12:22Z","timestamp":1741680742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use of Proton Pump Inhibitors Among Patients With Alcohol\u2010Related Cirrhosis\u2014A Danish Nationwide Cohort Study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-7928","authenticated-orcid":false,"given":"Marine S\u00f8lling","family":"Ramsing","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5137-7268","authenticated-orcid":false,"given":"Morten Daniel","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-1430","authenticated-orcid":false,"given":"Peter","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.02.031"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.019"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14012"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12065"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13061"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.615"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101104"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.036"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13615"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxad089"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102015\u2010309262"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3282f4aa01"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13827"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.678"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/clep.S179083"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/clep.S91125"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010014\u20109930\u20103"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_2_13_22_1","unstructured":"Sundhedsdatastyrelsen \u201cMEDSTAT.DK. 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