{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:01:47Z","timestamp":1791918107602,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Predicting clinical and virological outcomes in HBeAg\u2010negative (HBeAg\u2010neg) chronic infection often requires long\u2010term monitoring. Our study explored whether a single measurement of quantitative HBsAg (qHBsAg), HBV core\u2010related antigen (HBcrAg), and circulating HBV RNA (cirB\u2010RNA) can define the natural course of untreated HBeAg\u2010neg chronic infection patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To this aim, we included 128 na\u00efve HBeAg\u2010neg chronic infection patients, stratified according to qHBsAg levels in: (1) 10\u20131000\u2009IU\/mL, (2) 1000\u201310\u2009000\u2009IU\/mL, and (3) &gt;\u200910\u2009000\u2009IU\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HBcrAg and cirB\u2010RNA were detected in 27% and 19% of patients with qHBsAg &gt;\u20091000\u2009IU\/mL but rarely detected in patients with qHBsAg &lt;\u20091000\u2009IU\/mL. After a median follow\u2010up of 5.1\u2009years, 9.4% of patients lost HBsAg, and 8.5% experienced an increase in HBV DNA &gt;\u20092000\u2009IU\/mL. qHBsAg &lt;\u20091000\u2009IU\/mL was the only factor independently associated with functional cure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In untreated HBeAg\u2010neg chronic infection patients, single\u2010point cirB\u2010RNA and HBcrAg do not offer additional predictive value over qHBsAg &lt;\u20091000\u2009IU\/mL for spontaneous HBsAg loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.70072","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T10:21:36Z","timestamp":1745230896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>HBcrAg<\/scp> and <scp>cirB<\/scp>\u2010<scp>RNA<\/scp> Do Not Predict Clinical and Virological Outcomes in Patients With <scp>HBeAg<\/scp>\u2010Negative Chronic Infection"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0326-7088","authenticated-orcid":false,"given":"Sara","family":"Battistella","sequence":"first","affiliation":[{"name":"Liver Unit Hospital Cl\u00ednic, IDIBAPS  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2919-5676","authenticated-orcid":false,"given":"Thais","family":"Leonel","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Cl\u00ednic, IDIBAPS  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Barcelona 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