{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:12:02Z","timestamp":1772993522513,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Infections by multidrug resistant (MDR) bacteria are increasing and vary across regions and hospitals. We aimed to assess the epidemiology, prevalence, and outcomes of bacterial infections in patients with decompensated cirrhosis, comparing liver transplant (LT) and non\u2010LT centers in Catalonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a multicenter retrospective study including all patients with decompensated cirrhosis and bacterial infections hospitalised between January 2021 and 2022 from 5 university hospitals in the Barcelona metropolitan area. Two of them were LT centres. Clinical, laboratory, microbiological data, and in\u2010hospital mortality were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 576 infections were reported in 352 patients. LT centers had more health\u2010related infections, recurrent infections, and septic shock than non\u2010LT centers, while there were no differences in cirrhosis severity, acute\u2010on\u2010chronic liver failure (ACLF) or comorbidities. Although the most commonly isolated microorganisms and types of infection were similar in both centers, LT centers had higher rates of extended\u2010spectrum beta\u2010lactamase (12% vs. 6%), carbapenem (3% vs. 0%) and piperacillin\u2010tazobactam resistant bacteria (14% vs. 7%). MDR rate was also higher in LT centers (38% vs. 25%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and varied across hospitals (18%\u201342%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Furthermore, in\u2010hospital mortality was higher in LT centers (20% vs. 10%; <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Independent predictors of in\u2010hospital mortality were septic shock, ACLF, Child\u2010Pugh, age, and leukocyte count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study showed differences in epidemiology, prevalence of MDR infections, and outcomes across university hospitals, particularly between centers with and without LT. Further studies are warranted to unveil the nuances of bacterial infections across different healthcare institutions in Europe and elsewhere.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.70076","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T04:06:05Z","timestamp":1744344365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Bacterial Infections in Patients With Cirrhosis Between Hospitals With and Without Liver Transplant in Catalonia"],"prefix":"10.1111","volume":"45","author":[{"given":"Cl\u00e0udia","family":"Torras","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Department Parc Taul\u00ed University Hospital, Institut d'investigaci\u00f3 i innovaci\u00f3 Parc Taul\u00ed (I3PT\u2010CERCA), Universitat Aut\u00f2noma de Barcelona (UAB)  Sabadell 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Universitat de Barcelona\u2013IDIBELL  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta","family":"Cuy\u00e0s","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department Hospital de la Santa Creu i Sant Pau, CIBERehd  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Masnou","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Gastroenterology Department Germans Trias i Pujol University Hospital  Badalona Spain"},{"name":"Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain Universitat Aut\u00f2noma de Barcelona (UAB). 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