{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:12:15Z","timestamp":1759972335776,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006678","name":"Association Fran\u00e7aise pour l'Etude du Foie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006678","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Plasma cells (PCs) are frequently infiltrating livers from autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). However, the molecular pathway(s) implicated remain largely undefined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective in\u00a0situ study was performed to assess the cells and molecules involved in PC chemotactism and survival. Relevant in\u00a0vitro assays were conducted to confirm the activity of the identified molecules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that myeloid cells producing the PC survival factor a proliferation\u2010inducing ligand (APRIL) were present in livers from both diseases. Notably, APRIL density both at the level of producing cells and tissue retention of their secreted product correlated with PC accumulation in portal tracts from AIH but not PBC. PCs from AIH livers expressed the B\u2010cell maturation antigen and CD138 as the APRIL (co)receptors. Consequently, AIH liver PCs responded to APRIL stimulation with an increase in\u00a0vitro survival. We further identified IL\u201016 produced by infiltrating lymphocytes as a chemokine involved in PC recruitment. IL\u201016 expression also correlated with PC accumulation in portal spaces from AIH but again not from PBC. Follow\u2010up biopsies in AIH showed that treatment expectedly reduced PC density and affected in a similar way the density of APRIL\u2010producing cells. Notably, the density of secreted APRIL was less affected. Finally, the density of IL\u201016\u2010producing cells was not affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data show that PC infiltration and persistence is under the guidance of different pathways in AIH and PBC. In AIH, treatment leaves the PC chemotactism pathway unaffected, while partly downregulating the survival pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.70093","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T07:00:16Z","timestamp":1745823616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Pathways Orchestrate Plasma\u2010Cell Infiltration in Liver Autoimmunity Diseases"],"prefix":"10.1111","volume":"45","author":[{"given":"L.","family":"Baert","sequence":"first","affiliation":[{"name":"Institute for Advanced Biosciences, University Grenoble\u2010Alpes\/INSERM U1209\/CNRS  La Tronche France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Chemkhi","sequence":"additional","affiliation":[{"name":"T\u2010RAIG, TIMC, University Grenoble\u2010Alpes\/CNRS  La Tronche France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Manfroi","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, University Grenoble\u2010Alpes\/INSERM U1209\/CNRS  La Tronche France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mesples","sequence":"additional","affiliation":[{"name":"T\u2010RAIG, TIMC, University Grenoble\u2010Alpes\/CNRS  La Tronche France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"David\u2010Boudet","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Col","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Kanazawa University Graduate School of Medicine  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1358-6576","authenticated-orcid":false,"given":"B.","family":"Huard","sequence":"additional","affiliation":[{"name":"T\u2010RAIG, TIMC, University Grenoble\u2010Alpes\/CNRS  La Tronche France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sturm","sequence":"additional","affiliation":[{"name":"T\u2010RAIG, TIMC, University Grenoble\u2010Alpes\/CNRS  La Tronche France"},{"name":"Department of Pathology University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.17"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2017.10.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.267"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697617"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2018.05.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24757"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.10.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00041.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1886"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.10.016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2006.04.006"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-124669"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1811.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240201"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02500.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280203"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042309"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm861"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-001800"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaf6925"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs257"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.12.5945"},{"key":"e_1_2_10_25_1","first-page":"2928","article-title":"Lymphocyte Chemoattractant Factor Induces CD4\u2010Dependent Intracytoplasmic Signaling in Lymphocytes","volume":"146","author":"Cruikshank W. 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