{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:03:44Z","timestamp":1787889824392,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P500PM_217670"],"award-info":[{"award-number":["P500PM_217670"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P500PM_210866"],"award-info":[{"award-number":["P500PM_210866"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Health\u2010related outcomes through early adulthood among offspring prenatally exposed to maternal metabolic dysfunction\u2010associated steatotic liver disease (MASLD) are insufficiently investigated. We aimed to study the risk of mortality and cancer in such offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This nationwide cohort study included all singleton live born offspring with prenatal exposure to maternal biopsy\u2010proven MASLD (1992\u20132017;\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009239) in Sweden. MASLD offspring were matched with up to five reference offspring (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20091131) of mothers without known MASLD by maternal age at delivery, calendar year of delivery, and parity. We used a multivariable Cox proportional hazard model to calculate adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) for mortality and cancer up until 31 December 2021. For mortality, we stratified by maternal MASLD severity (simple steatosis alone vs. severe MASLD comprising steatohepatitis, liver fibrosis or cirrhosis).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a median follow\u2010up of 16.9\u2009years, two deaths occurred in offspring prenatally exposed to maternal MASLD (IR 0.5\/1000 person\u2010years, 95% CI 0.1\u20131.8) and seven deaths in reference offspring (IR 0.4\/1000 person\u2010years, 95% CI 0.1\u20130.8), which corresponded to an aHR of 1.78 (95% CI 0.27\u201311.97). Higher disease severity was not associated with an increased risk of death. We observed few cancer events with similar IR\/1000 person\u2010years (0.2 [95% CI 0.0\u20131.4] vs. 0.3 [0.1\u20130.6] in reference offspring), which corresponded to an aHR of 0.64 (95% CI 0.07\u20135.95).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found no evidence that prenatal exposure to maternal MASLD affects the risk of death or cancer through early adulthood but larger studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70174","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:04:44Z","timestamp":1749726284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mortality and Cancer in Offspring of Mothers With Biopsy\u2010Proven\n                    <scp>MASLD<\/scp>\n                    During Pregnancy: A Nationwide Cohort Study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4688-8223","authenticated-orcid":false,"given":"Carole A.","family":"Marxer","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahim","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Gastroenterology and Hepatology University Digestive Health Care Center Basel \u2010 Clarunis  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm 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