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Several laboratory tests can help distinguish patients with advanced fibrosis or cirrhosis but their utility in discriminating earlier histological stages of fibrosis is unclear. A current shift toward non\u2010invasive radiological methods, such as vibration\u2010controlled transient elastography, shear wave elastography, acoustic radiation force impulse imaging and magnetic resonance elastography, opens promising avenues for their wide application; however, their performances may be compromised by hepatic inflammation, ascites, biliary obstruction, or concomitant obesity and metabolic dysfunction\u2010associated steatotic liver disease. Corticosteroids and immunomodulators have been shown to regress fibrosis in AIH patients. In PBC, treatment with either synthetic bile acids, farnesoid X receptor agonists or peroxisome proliferator\u2010activated receptor agonist leads to the improvement or stabilization in the fibrosis stage. There is an urgent need for effective medical treatment in PSC, and available evidence of antifibrotic treatment is particularly limited. Promising anti\u2010fibrotic interventions in AILD encompass conventional pharmacological agents as well as potential new treatments, such as fibrates, monoclonal antibodies, and site\u2010 and organelle\u2010specific agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70190","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T08:24:50Z","timestamp":1752913490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pathogenesis, Non\u2010Invasive Assessments and Treatment of Hepatic Fibrosis in Autoimmune Liver Diseases"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5651-9010","authenticated-orcid":false,"given":"Ellina","family":"Lytvyak","sequence":"first","affiliation":[{"name":"Division of Preventive Medicine, Department of Medicine University of Alberta  Edmonton 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