{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:58:49Z","timestamp":1790812729219,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Hepatitis C virus (HCV) treatment rate was low in China. We aimed to evaluate a four\u2010support approach in linking previous HCV RNA\u2010positive patients to antiviral treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a randomised controlled trial (ChiCTR2200060858,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.chictr.org.cn\">https:\/\/www.chictr.org.cn<\/jats:ext-link>\n                      ) and selected HCV RNA\u2010positive participants from previous HCV antibody\/RNA\u2010positive patients, and assigned them into intervention or control arm. The control arm received routine care, whereas intervention arm received additional four\u2010support intervention, including simplified treatment delivery, minimal examinations, insurance assistance, and social supports. The primary outcome was proportion of treatment initiation. The secondary outcomes included sustained virologic response (SVR) rates, time\u2010to\u2010treatment initiation, treatment completion, and treatment willingness. Adverse events were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Among 394 participants, 199 and 195 were in the four\u2010support and control arms, respectively. The four\u2010support arm had significant higher proportions of treatment initiation than control arm at 1 and 2\u2009months (35.68% vs. 13.85% and 47.24% vs. 17.44%, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). SVR was confirmed in 74.47% of four\u2010support arm compared with 61.76% of control arm (adjusted odds ratio [aOR] 2.06). Patients in four\u2010support arm had a shorter time\u2010to\u2010treatment initiation (adjusted hazard ratio [aHR] 3.10) and more frequent treatment completion (aOR 4.13) than control arm. The cumulative probability of treatment initiation at 1 and 2\u2009months had a significant difference between two arms. Only one adverse event occurred in four\u2010support arm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The four\u2010support intervention could improve both antiviral treatment initiation and SVR in HCV RNA\u2010positive patients with a previous HCV antibody\/RNA\u2010positive result and could be applied in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70200","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T05:36:44Z","timestamp":1751002604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Multifaceted Approach Leads to Improved Linkage to\n                    <scp>HCV<\/scp>\n                    Therapy: A Multicenter Randomised Controlled Trial"],"prefix":"10.1111","volume":"45","author":[{"given":"Peng","family":"Xu","sequence":"first","affiliation":[{"name":"National Center for AIDS\/STD Control and Prevention Chinese Center for Disease Control and Prevention  Beijing China"},{"name":"Department of Infection Prevention and Control The First Affiliated Hospital of Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute for AIDS\/STD Control and Prevention Jiangsu Center for Disease Control and Prevention  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute for AIDS\/STD Control and Prevention Yunnan Center for Disease Control and Prevention  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejun","family":"Yu","sequence":"additional","affiliation":[{"name":"National Center for AIDS\/STD Control and Prevention Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for AIDS\/STD Control and Prevention Yunnan Center for Disease Control and Prevention  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for AIDS\/STD Control and Prevention Yunnan Center for Disease Control and Prevention  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanwu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of AIDS\/STD Control and Prevention Xuzhou Center for Disease Control and Prevention  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention Wenshan Zhuang and Miao Autonomous Prefecture Center for Disease Control and Prevention  Wenshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of AIDS\/STD Control and Prevention Xuzhou Center for Disease Control and Prevention  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongfu","family":"Liu","sequence":"additional","affiliation":[{"name":"National Center for AIDS\/STD Control and Prevention Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2799-0051","authenticated-orcid":false,"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for AIDS\/STD Control and Prevention Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61838-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093057"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01320-X"},{"key":"e_1_2_10_5_1","unstructured":"World Health Organization \u201cHepatitis C \u201dWHO Fact Sheet No. 164 (2014) updated July 2015 http:\/\/www.who.int\/mediacentre\/factsheets\/fs164_apr2014\/en\/."},{"key":"e_1_2_10_6_1","volume-title":"Progress Report on 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