{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:54:45Z","timestamp":1792119285694,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS2025\u201000517677"],"award-info":[{"award-number":["RS2025\u201000517677"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS2023\u201000270936"],"award-info":[{"award-number":["RS2023\u201000270936"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Plastic particles are a global pollution problem, and humans are potentially exposed to them. Ingested plastic particles, microparticles (MPs) and nanoparticles (NPs), predominantly accumulate in the liver and cause hepatotoxicity through oxidative stress and metabolic dysfunction. NPs promote more toxic actions than MPs; however, the mechanisms involved in developing and progressing metabolic dysfunction\u2010associated steatotic liver disease (MASLD) from chronic exposure to NPs remain poorly understood. Hedgehog (Hh) signalling regulates MASLD pathogenesis. Herein, we investigated the pathophysiological effects of NPs in MASLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mice were orally administered NPs via drinking water while fed a choline\u2010deficient, L\u2010amino acid\u2010defined, high\u2010fat diet (CDAHFD) for 12\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NPs increased lipid accumulation in hepatocytes and apoptosis. Moreover, these actions were enhanced in lipotoxicity\u2010exposed hepatocytes. Chronically exposed NPs accumulated in mice livers and aggravated CDAHFD\u2010induced hepatic damage, especially fibrosis. Activated Hh signalling in the CDAHFD group was elevated by NP treatment. Increased Sonic Hh expression in the hepatocytes of NP\u2010treated mice in the CDAHFD group triggered Hh signalling in hepatic stellate cells (HSCs), which promoted liver fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results demonstrate that chronic exposure to NPs increases vulnerability to MASLD progression, suggesting that NPs are a potentially harmful factor in the development and progression of liver disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70224","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T11:30:58Z","timestamp":1752492658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Chronic Nanoplastic Exposure Promotes the Development and Progression of Metabolic Dysfunction\u2010Associated Steatotic Liver Disease"],"prefix":"10.1111","volume":"45","author":[{"given":"Jinsol","family":"Han","sequence":"first","affiliation":[{"name":"Institution of Systems Biology Pusan National University  Pusan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Integrated Biological Science College of Natural Science, Pusan National University  Pusan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanbin","family":"Lee","sequence":"additional","affiliation":[{"name":"Institution of Systems Biology Pusan National University  Pusan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2747-6685","authenticated-orcid":false,"given":"Ahyeon","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Integrated Biological Science College of Natural Science, Pusan National 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