{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:22:09Z","timestamp":1761164529858,"version":"build-2065373602"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019\u201001140"],"award-info":[{"award-number":["2019\u201001140"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The relationship between skeletal muscle features and hepatic fat infiltration remains understudied. To address this knowledge gap, a cross\u2010sectional observational study was conducted using data from two ancillary studies of the SCAPIS cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      The study aimed to examine the relationship between skeletal thigh muscle radiodensity (Hounsfield Units, HU) and area (cm\n                      <jats:sup>2<\/jats:sup>\n                      ), and metabolic dysfunction\u2010associated steatotic liver disease (MASLD) and hepatic radiodensity (HU). Multivariable linear regression analyses were applied to data from 4620 participants (52% women) with a mean age of 57.9\u2009years. Adjustments for confounders were computed in four theoretical models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Results showed a positive significant association between thigh muscle area and MASLD (OR\u2009=\u20091.29, 95% CI 1.02, 1.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), and a negative association with hepatic radiodensity (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u2009\u22120.76, 95% CI \u22121.19, \u22120.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), independent of muscle radiodensity. Additionally, a significant association was observed between muscle radiodensity and hepatic radiodensity (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u20090.37, 95% 0.09, 0.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). Finally, sex differences were notable in the association between thigh muscle area and MASLD (\n                      <jats:italic>F<\/jats:italic>\n                      \u2010test\u2009=\u20090.10). Specifically, we observed statistically significant associations between thigh muscle features and liver density\/MASLD in men, but not in women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Conclusively, increased thigh muscle volume was associated with greater odds of MASLD and hepatic steatosis, independent of muscle radiodensity. Yet, greater thigh muscle radiodensity was associated with decreased odds of hepatic steatosis, regardless of the muscle volume. Furthermore, a sex difference was observed in our study, underscoring the importance of considering sex\u2010specific factors on the development of MASLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70239","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T13:27:56Z","timestamp":1753277276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thigh Muscles and Metabolic Dysfunction\u2010Associated Steatotic Liver Disease: Findings From the\n                    <scp>SCAPIS<\/scp>\n                    \/\n                    <scp>IGT<\/scp>\n                    \u2010Microbiota Study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2774-0194","authenticated-orcid":false,"given":"Amar","family":"Osmancevic","sequence":"first","affiliation":[{"name":"General Practice\/Family Medicine School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Gummesson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine, Sahlgrenska Academy, Gothenburg University  Gothenburg Sweden"},{"name":"Department of Clinical Genetics and Genomics Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Allison","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine School of Medicine, UC San Diego  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Kullberg","sequence":"additional","affiliation":[{"name":"Radiology, Department of Surgical Sciences Uppsala University  Sweden"},{"name":"Antaros Medical  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"General Practice\/Family Medicine School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine, Sahlgrenska Academy, Gothenburg University  Gothenburg Sweden"},{"name":"Department of Clinical Physiology Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bledar","family":"Daka","sequence":"additional","affiliation":[{"name":"General Practice\/Family Medicine School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"volume-title":"StatPearls Publishing Copyright 2024","year":"2024","author":"Panuganti K. 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