{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:47:31Z","timestamp":1793803651818,"version":"4.6.1"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>There is uncertainty regarding the hepatic efficacy of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) in metabolic dysfunction\u2010associated steatotic liver disease (MASLD) or steatohepatitis (MASH). We performed a meta\u2010analysis of randomised controlled trials (RCTs) to examine the efficacy of GLP\u20101RAs in treating MASLD or MASH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched three electronic databases from inception until April 2025 to identify RCTs examining the efficacy of GLP\u20101RAs for the treatment of MASLD or MASH. The outcome measures included MASH resolution without worsening of fibrosis or improvement in at least one stage of fibrosis without worsening of MASH, along with reductions in liver fat content measured using magnetic resonance\u2010based techniques. Meta\u2010analysis was conducted using random\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 13 phase 2 or phase 3 RCTs (1811 participants). These trials diagnosed MASLD or MASH through liver biopsy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) or magnetic resonance\u2010based techniques (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099). Regardless of diabetes status, among individuals with MASH and moderate\u2010to\u2010advanced fibrosis, GLP\u20101RAs (especially semaglutide 2.4\u2009mg\/week) for up to 72\u2009weeks were superior to placebo in achieving MASH resolution (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093 RCTs; pooled random\u2010effects odds ratio 3.48, 95% CI 2.69\u20134.51;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%), and in improving liver fibrosis (pooled odds ratio 1.79, 95% CI 1.37\u20132.35;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). Among individuals with MASH\u2010related compensated cirrhosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091 RCT available only), semaglutide did not lead to MASH resolution or improved fibrosis compared to placebo. Furthermore, GLP\u20101RAs reduced magnetic resonance\u2010measured liver fat content (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099; pooled mean difference: \u22124.50%, 95% CI \u22126.60 to \u22122.40%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200995.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101RAs are a promising treatment option for MASLD or MASH. Further research is needed to evaluate the long\u2010term effects of GLP\u20101RAs on liver\u2010related clinical events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70256","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:45:33Z","timestamp":1753875933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Glucagon\u2010Like Peptide\u20101 Receptor Agonists Improve\n                    <scp>MASH<\/scp>\n                    and Liver Fibrosis: A Meta\u2010Analysis of Randomised Controlled Trials"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-6329","authenticated-orcid":false,"given":"Alessandro","family":"Mantovani","sequence":"first","affiliation":[{"name":"Metabolic Diseases Research Unit IRCCS Sacro Cuore \u2013 Don Calabria Hospital  Negrar di Valpolicella Italy"},{"name":"Department of Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Morandin","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine University and Azienda Ospedaliera Universitaria Integrata of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Fiorio","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine University and Azienda Ospedaliera Universitaria Integrata of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Lando","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine University and Azienda Ospedaliera Universitaria Integrata of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2186-9595","authenticated-orcid":false,"given":"Norbert","family":"Stefan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Institute of Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-2579","authenticated-orcid":false,"given":"Herbert","family":"Tilg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism Medical University Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-7753","authenticated-orcid":false,"given":"Christopher D.","family":"Byrne","sequence":"additional","affiliation":[{"name":"National Institute for Health and Care Research, Southampton Biomedical Research Centre, University Hospital Southampton and University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-3900","authenticated-orcid":false,"given":"Giovanni","family":"Targher","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Research Unit IRCCS Sacro Cuore \u2013 Don Calabria Hospital  Negrar di Valpolicella Italy"},{"name":"Department of Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0431"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101271"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00020-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00159-0"},{"issue":"4","key":"e_1_2_10_6_1","first-page":"691","article-title":"MASLD: A Systemic Metabolic Disorder With Cardiovascular and Malignant Complications","volume":"73","author":"Targher G.","year":"2024","journal-title":"Gut"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15930"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-024-00582-z"},{"issue":"4","key":"e_1_2_10_9_1","first-page":"573","article-title":"Thyroid Hormone Receptor\u2010Beta Agonists: New MASLD Therapies on the Horizon","volume":"73","author":"Byrne C. 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