{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:43:28Z","timestamp":1783691008529,"version":"3.55.0"},"reference-count":65,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\n                      Cholangiocarcinoma (CCA) is one of the most prevalent primary liver malignancies with increasing incidence and mortality rates, particularly in Southeast Asia. Surgical resection is a primary therapeutic option offered to patients with localised disease. Unfortunately, early disease recurrence is common and robust tools for tailored patient\u2010centric post\u2010operative management and follow\u2010up schemes are highly desired but currently lacking. To address this unmet clinical need, this study investigated the clinical utility of the single nucleotide polymorphisms (SNPs) in DNA repair genes (\n                      <jats:italic>ERCC5 rs1047768, APEX1 rs1130409, PARP1 rs1805414, XPC rs2228001<\/jats:italic>\n                      and\n                      <jats:italic>ERCC5 rs873601<\/jats:italic>\n                      ) and patient prognosis after curative intent surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort of 229 patients who underwent surgical treatment for intrahepatic (iCCA) and perihilar (pCCA) cholangiocarcinoma was examined. Kaplan\u2013Meier and multivariable Cox regression analyses were used to assess the impact of these SNPs on recurrence\u2010free survival (RFS), cancer\u2010specific survival (CSS) and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Within comprehensive multivariable analyses, the TT genotype of\n                      <jats:italic>XPC rs2228001<\/jats:italic>\n                      was significantly associated with prolonged RFS (GG\/GT\u2009=\u20091, HR\u2009=\u20090.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027), CSS (HR\u2009=\u20090.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018) and OS (HR\u2009=\u20090.31;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) in iCCA. Similarly, in pCCA, the TT genotype\n                      <jats:italic>of XPC rs2228001<\/jats:italic>\n                      was an independent prognostic factor for prolonged CSS (GG\/GT\u2009=\u20091, HR\u2009=\u20090.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings suggest that SNPs in DNA repair genes, particularly\n                      <jats:italic>XPC rs2228001<\/jats:italic>\n                      , play a crucial role in modulating the prognosis of CCA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70292","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:14:46Z","timestamp":1755695686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Prognostic Value of the\n                    <i>XPC rs2228001<\/i>\n                    Single Nucleotide Polymorphism in Cholangiocarcinoma"],"prefix":"10.1111","volume":"45","author":[{"given":"Guanwu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Surgery and Transplantation University Hospital RWTH Aachen  Aachen Germany"},{"name":"Department of Hepatobiliary Surgery Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University)  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mantas","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation University Hospital RWTH Aachen  Aachen Germany"},{"name":"Department of Surgery and Transplantation University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarick M.","family":"Al\u2010Masri","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation University Hospital RWTH Aachen  Aachen Germany"},{"name":"University of Applied Science Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smiths Sengkwawoh","family":"Lueong","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK), Partner Site Essen, a Partnership Between German Cancer Research Center (DKFZ) and University Hospital Essen  Essen Germany"},{"name":"Bridge Institute of Experimental Tumor Therapy (BIT) and Division of Solid Tumor Translational Oncology (DKTK), west German Cancer Center, University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Siveke","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK), Partner Site Essen, a Partnership Between German Cancer Research Center (DKFZ) and University Hospital Essen  Essen Germany"},{"name":"Bridge Institute of Experimental Tumor Therapy (BIT) and Division of Solid Tumor Translational Oncology (DKTK), west German Cancer Center, University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Luedde","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Heinrich Heine University Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom F.","family":"Ulmer","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation University Hospital RWTH Aachen  Aachen Germany"},{"name":"Department of Surgery and Transplantation University Hospital Essen  Essen Germany"},{"name":"Department of Surgery Maastricht University Medical Centre (MUMC)  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iakovos","family":"Amygdalos","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian W. 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