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Although MASLD serves as an umberlla term, its subtype of metabolic dysfunction associated steatohepatitis (MASH) with a prevalence of 5\u20107%, can lead to adverse liver outcomes including cirrhosis and liver mortality. However, prevalence rates for MASLD\/MASH vary by country and region of the world. With the increasing rates of type 2 diabetes and obesity, MASLD\/MASH is increasing and is currently among the top causes of hepatocellular carcinoma and an indication for liver transplantation in the United States. Therefore, the care model is shifting to prevention given this large clinical, economic and humanistic burden of this liver disease. As in other noncommunicable diseases, interventional priorities for policymakers should be focused on building infrastructure that supports physical activity and healthy food choices as well as access to approved treatments for MASLD. At the same time, identifying individuals at risk for adverse outcomes using non\u2010invasive tests and developing individual care plans that address the needs of each patient with MASLD, including their mental and physical health, should be a focus for healthcare providers. Furthermore, raising awareness among patients, the public and healthcare providers continues to be a crucial need. This report will provide recommendations for policymakers to provide the needed interventions to reverse the current trajectory of this liver disease.<\/jats:p>","DOI":"10.1111\/liv.70311","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T12:36:15Z","timestamp":1758112575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Managing\n                    <scp>MASLD<\/scp>\n                    Through Preventive Hepatology: Integrating Policy Reform, Public Health and Personalised Care"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-577X","authenticated-orcid":false,"given":"Zobair M.","family":"Younossi","sequence":"first","affiliation":[{"name":"The Global MASH Council  Washington DC USA"},{"name":"Beatty Liver and Obesity Research Program Inova Health System  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2215-9410","authenticated-orcid":false,"given":"Vincent Wai\u2010Sun","family":"Wong","sequence":"additional","affiliation":[{"name":"The Global MASH Council  Washington DC USA"},{"name":"Medical Data Analytics Center, Department of Medicine and Therapeutics The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel A.","family":"Tsochatzis","sequence":"additional","affiliation":[{"name":"The Global MASH Council  Washington DC USA"},{"name":"UCL Institute for Liver and Digestive Health Royal Free Hospital and UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Castera","sequence":"additional","affiliation":[{"name":"The Global MASH Council  Washington DC USA"},{"name":"Department of Hepatology, Beaujon Hospital, AP\u2010HP Universit\u00e9 Paris\u2010Cit\u00e9  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Betel","sequence":"additional","affiliation":[{"name":"The Global MASH Council  Washington DC USA"},{"name":"Fatty Liver Alliance  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-6124","authenticated-orcid":false,"given":"Linda","family":"Henry","sequence":"additional","affiliation":[{"name":"The Global MASH Council  Washington DC USA"},{"name":"Beatty Liver and Obesity Research Program Inova Health System  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-7497","authenticated-orcid":false,"given":"Shira Zelber","family":"Sagi","sequence":"additional","affiliation":[{"name":"The Global MASH Council  Washington DC USA"},{"name":"School of Public Health University of Haifa  Haifa Israel"},{"name":"Center for Outcomes Research in Liver Diseases  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010214"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(24)00193\u20106"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)00204\u20106"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.04.031"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000678"},{"key":"e_1_2_14_8_1","unstructured":"World Health Organization \u201cMore Ways to Save More Lives for Less Money: World Health Assembly Adopts More Best Buys to Tackle Noncommunicable Diseases \u201daccessed June 9 2025 https:\/\/www.who.int\/news\/item\/26\u201005\u20102023\u2010more\u2010ways\u2010\u2010to\u2010save\u2010more\u2010lives\u2010\u2010for\u2010less\u2010money\u2010\u2010\u2010\u2010world\u2010health\u2010assembly\u2010adopts\u2010more\u2010best\u2010buys\u2010\u2010to\u2010tackle\u2010noncommunicable\u2010diseases."},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(24)00220\u20106"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2022.12.005"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000004"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.021"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.03.006"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1599"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18451"},{"key":"e_1_2_14_16_1","unstructured":"Z. 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