{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:10:07Z","timestamp":1793725807201,"version":"4.6.1"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatocellular carcinoma (HCC) is a leading cause of cancer\u2010related mortality. Transarterial chemoembolization (TACE) is the standard locoregional therapy for unresectable HCC but is limited by high recurrence and hepatic toxicity. Low\u2010molecular\u2010weight fucoidan (LMF), a sulfated polysaccharide from brown seaweed, has anticancer and hepatoprotective properties. This study assessed whether LMF enhances tumour response and preserves liver function when combined with TACE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomised, double\u2010blind, placebo\u2010controlled trial, 82 patients with unresectable HCC were randomly assigned (1:1) to receive LMF (4.4\u2009g twice daily) or placebo for 6 months in addition to TACE. Tumour response was assessed using modified RECIST criteria, and liver function was monitored via Child\u2013Pugh classification. The primary endpoint was disease control rate (DCR), with objective response rate (ORR), liver function and adverse events as secondary endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics were well balanced. DCR was significantly higher in the LMF group (95.24% vs. 80.00%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035), with a lower progressive disease rate (4.76% vs. 20.00%). ORR was higher in the LMF group (52.38% vs. 35.00%) but not statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.1129). LMF preserved liver function (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029), with more patients maintaining Child\u2013Pugh Class A (80.95% vs. 62.50%). Adverse event rates were similar, and no severe adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LMF improved tumour control, preserved liver function and had a favourable safety profile. These findings suggest LMF may mitigate TACE\u2010related hepatic toxicity and prolong treatment eligibility, warranting further validation in larger trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70347","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T12:49:14Z","timestamp":1758113354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fucoidan Improves Tumour Control and Liver Function in\n                    <scp>TACE<\/scp>\n                    for Unresectable Hepatocellular Carcinoma: A Randomised Trial"],"prefix":"10.1111","volume":"45","author":[{"given":"Yanting","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital (Xiamen) Fudan University  Xiamen 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