{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:22:46Z","timestamp":1780050166695,"version":"3.53.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Despite the availability of highly effective direct\u2010acting antivirals, undiagnosed and untreated hepatitis C virus (HCV) infections remain a major obstacle to achieving WHO elimination targets. This study evaluated the feasibility and effectiveness of a local micro\u2010elimination initiative aimed at identifying, retrieving and re\u2010linking previously diagnosed but not treated individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of anti\u2010HCV test records from 2014 to 2020 in the AUSL Romagna area identified all individuals with a positive anti\u2010HCV test and either confirmed or possible chronic HCV infection. Eligible cases were prospectively contacted first by phone, then by letter, and invited for clinical reassessment and antiviral therapy evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 6859 individuals with a previous positive anti\u2010HCV test, 2719 were identified as potentially viremic. Of these, 704 met eligibility criteria and were contacted. A total of 485 individuals were successfully reached (68.9%), 214 attended clinical reassessment and 160 were found to have active infection. Antiviral therapy was initiated in 127 patients (79.4%), with 100% achieving sustained virologic response. Advanced fibrosis or cirrhosis was present in 18.7%, and hepatobiliary malignancies were newly diagnosed in four patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This targeted retrieval strategy demonstrates that re\u2010linkage of previously diagnosed HCV patients lost to follow\u2010up is feasible and effective. Scaling up similar structured program could significantly contribute to national HCV elimination efforts by recovering hidden reservoirs of infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70354","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T16:58:15Z","timestamp":1758214695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification and Retrieval of Untreated\n                    <scp>HCV<\/scp>\n                    \u2010Infected Individuals Lost to Follow\u2010Up in Italy: Results From the\n                    <scp>RECALL<\/scp>\n                    Project"],"prefix":"10.1111","volume":"45","author":[{"given":"Fabio","family":"Conti","sequence":"first","affiliation":[{"name":"Internal Medicine Unit Infermi Hospital, AUSL Romagna  Faenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese Della","family":"Vittoria","sequence":"additional","affiliation":[{"name":"Infectious Diseases Operative Unit S. Maria delle Croci Hospital, AUSL Romagna  Ravenna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Liverani","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit Forl\u00ec\u2010Cesena Hospital, AUSL Romagna  Forl\u00ec\u2010Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Briganti","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit Forl\u00ec\u2010Cesena Hospital, AUSL Romagna  Forl\u00ec\u2010Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Di Cesare","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit Morgagni\u2010Pierantoni Hospital, AUSL Romagna  Forl\u00ec\u2010Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Tirotta","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit Morgagni\u2010Pierantoni Hospital, AUSL Romagna  Forl\u00ec\u2010Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Larn\u00e8","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit Infermi Hospital, AUSL Romagna  Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit Infermi Hospital, AUSL Romagna  Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Grassi","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit Cervesi Hospital, AUSL Romagna  Cattolica Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bassi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Operative Unit S. Maria delle Croci Hospital, AUSL Romagna  Ravenna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cristini","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit Forl\u00ec\u2010Cesena Hospital, AUSL Romagna  Forl\u00ec\u2010Cesena Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC) Alma Mater Studiorum, University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit Forl\u00ec\u2010Cesena Hospital, AUSL Romagna  Forl\u00ec\u2010Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Muratori","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit Morgagni\u2010Pierantoni Hospital, AUSL Romagna  Forl\u00ec\u2010Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Biagetti","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit Infermi Hospital, AUSL Romagna  Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Secomandi","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit Infermi Hospital, AUSL Romagna  Faenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Napoli","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit Infermi Hospital, AUSL Romagna  Faenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Borghi","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit Infermi Hospital, AUSL Romagna  Faenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigina Vanessa","family":"Alemanni","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit Forl\u00ec\u2010Cesena Hospital, AUSL Romagna  Forl\u00ec\u2010Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Gianfreda","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit Infermi Hospital, AUSL Romagna  Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Angelini","sequence":"additional","affiliation":[{"name":"Operative Unit of Hygiene and Public Health\u2010Ravenna S. 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