{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:13:12Z","timestamp":1794269592298,"version":"4.9.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM21\/00081"],"award-info":[{"award-number":["CM21\/00081"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00609"],"award-info":[{"award-number":["PI20\/00609"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/00013"],"award-info":[{"award-number":["PI22\/00013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008318","name":"Asociaci\u00f3n Espa\u00f1ola para el Estudio del H\u00edgado","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016391","name":"Societat Catalana de Digestologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["grant 2021_SGR_01322"],"award-info":[{"award-number":["grant 2021_SGR_01322"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Nucleos(t)ide analogues (NAs) discontinuation in HBeAg\u2010negative chronic hepatitis B (CHB) aims at increasing functional cure rates. However, clinical outcomes and predictive factors for HBsAg loss or re\u2010treatment are affected by the heterogeneity of studies. We aimed to analyse baseline factors associated with outcomes after NAs discontinuation in a cohort with homogeneous re\u2010treatment criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective multicenter study of 149 HBeAg\u2010negative CHB with complete viral suppression and absence of cirrhosis recruited from 2016 to 2021. Re\u2010treatment criteria after NAs discontinuation were homogeneous based on liver tests and HBV\u2010DNA levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this predominantly Caucasian cohort, 71% received tenofovir with a median treatment duration of 10 (7\u201313) years. Forty patients (27%) achieved HBsAg loss after 44 (28\u201354) months. Lower qHBsAg at end of treatment (EOT) and longer treatment duration were independent predictors of HBsAg loss. Combining qHBsAg at EOT (1000\u2009IU\/mL) and month 3 after NA interruption (100\u2009IU\/mL) stratified patients into high (&gt;\u200970%) or low (&lt;\u200910%) likelihood of HBsAg loss. On the other hand, 43 (29%) patients were retreated; HBV\u2010DNA\u2009&lt;\u2009100\u2009IU\/mL at month 3 was significantly associated with remaining off\u2010therapy. Overall, safety was favourable, with mild or transient ALT flares occurring in 64 patients (43%). However, one patient (0.6%) developed a severe hepatitis and required liver transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NA withdrawal results in functional cure rates exceeding 25%, particularly in patients with long\u2010term antiviral treatment and low qHBsAg levels. Combining qHBsAg levels at EOT and at 3\u2009months accurately stratifies patients according to the probability of HBsAg loss. Close monitoring to detect the need for treatment re\u2010introduction is mandatory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70371","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T06:46:32Z","timestamp":1760424392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Determinants of\n                    <scp>HBsAg<\/scp>\n                    Loss After Nucleos(t)ide Discontinuation in a Prospective Cohort of\n                    <scp>HBeAg<\/scp>\n                    \u2010Negative Caucasian Patients"],"prefix":"10.1111","volume":"45","author":[{"given":"Anna","family":"Pocurull","sequence":"first","affiliation":[{"name":"Liver Unit, Hospital Cl\u00ednic, IDIBAPS  Barcelona Spain"},{"name":"CIBEREHD  Madrid Spain"},{"name":"Faculty of Medicine University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Broquetas","sequence":"additional","affiliation":[{"name":"Liver Unit, Gastroenterology Department. Hospital del Mar. Department of Medicine and Life Sciences, Universitat Pompeu Fabra IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Hoyas","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Universitario de Valme  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Universitario Central de Asturias University of Oviedo ISPA  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Miquel","sequence":"additional","affiliation":[{"name":"CIBEREHD  Madrid Spain"},{"name":"Liver Unit, Digestive Service in Universitary Hospital Parc Tauli, Institut d'Investigaci\u00f3 I Innovaci\u00f3 I3PT, Departament de Medicina de la Universitat Aut\u00f2noma de Barcelona Universitat de Vic, Universitat Central de Catalunya  Vic Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Microbiology Department Hospital Universitario Central de Asturias, ISPA  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Amiama","family":"Roig","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Universitario La Paz, IdiPAZ Universidad Aut\u00f3noma de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6459-5052","authenticated-orcid":false,"given":"Queralt","family":"Herms","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Cl\u00ednic, IDIBAPS  Barcelona Spain"},{"name":"CIBEREHD  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Rodr\u00edguez\u2010Tajes","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Cl\u00ednic, IDIBAPS  Barcelona Spain"},{"name":"CIBEREHD  Madrid Spain"},{"name":"Faculty of Medicine University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Garc\u00eda\u2010Samaniego","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Universitario La Paz, IdiPAZ Universidad Aut\u00f3noma de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Universitario de Valme  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Buti","sequence":"additional","affiliation":[{"name":"Liver Unit. 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