{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:22:45Z","timestamp":1789521765190,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Alcohol\u2010associated liver disease (ALD) is a current unmet clinical challenge attributed to a lack of effective pharmacological therapy. Yes\u2010associated protein (YAP) is a transcriptional co\u2010activator and has been extensively investigated in liver diseases. However, the role of YAP in ALD is still unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The early ALD mouse model was induced using a Gao\u2010binge diet. Furthermore, the function of hepatic YAP in ALD was investigated using YAP\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice, mice injected with an adeno\u2010associated virus (AAV) 9\u2010delivered saCas9\/sgYAP system (AAV9\u2010saCas9\/sgYAP), or YAP\n                      <jats:sup>\u0394Hep<\/jats:sup>\n                      mice fed the Gao\u2010binge diet. The mechanisms underlying hepatocellular YAP\u2010regulated ALD were further studied in the YAP\n                      <jats:sup>\u0394Hep<\/jats:sup>\n                      mice. The therapeutic efficacy of hepatocellular YAP expression was tested using AAV8\u2010delivered YAP overexpression in mice fed the Gao\u2010binge diet.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In response to the Gao\u2010binge diet, whole\u2010body YAP deficiency exacerbated early ALD\u2010related phenotypes in mice, including hepatic steatosis and inflammatory response. Furthermore, the YAP\n                      <jats:sup>\u0394Hep<\/jats:sup>\n                      mice also exhibited aggravated ALD\u2010related phenotypes. However, hepatocyte\u2010specific YAP or YAP (5S) overexpression substantially reversed the disease progression in the YAP\n                      <jats:sup>\u0394Hep<\/jats:sup>\n                      mice. Mechanistically, hepatocellular YAP inhibited hepatic steatosis, inflammatory response and fibrosis through down\u2010regulating CD36. Furthermore, the oncostatin (OSM)\u2013STAT3 axis was involved in YAP\u2010mediated regulation of CD36. Notably, we also found that AAV8\u2010Alb\u2010YAP effectively ameliorated the progression of early ALD in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hepatocellular YAP functions as a negative regulator of pathological changes by inhibiting the OSM\u2010STAT3\u2010CD36 pathway during early ALD, representing a potential therapeutic target for early ALD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70372","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:20:11Z","timestamp":1758936011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Yes\u2010Associated Protein in Hepatocytes Protects Against Early Alcohol\u2010Associated Liver Disease"],"prefix":"10.1111","volume":"45","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Basic and Translational Medicine Xi'an Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinpu","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Basic and Translational Medicine Xi'an Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Basic and Translational Medicine Xi'an Medical University  Xi'an Shaanxi China"},{"name":"School of Basic and Medical Sciences Xi'an Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaohong","family":"Qin","sequence":"additional","affiliation":[{"name":"Institute of Basic and Translational Medicine Xi'an Medical University  Xi'an Shaanxi 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