{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:33:04Z","timestamp":1784302384560,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300608"],"award-info":[{"award-number":["82300608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The hepatic inflammatory infiltrates in patients with primary biliary cholangitis (PBC) contain variable numbers of B cells and plasma cells; however, their potential as therapeutic targets remains uncertain. This study aims to investigate the pathological characteristics and therapeutic implications of plasma cells and B cells in PBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected liver tissue from 55 PBC patients, alongside serological data from the time of sampling and 1\u2009year following ursodeoxycholic acid (UDCA) treatment. To evaluate the effects of plasma cell and B cell depletion, we utilised dnTGF\u2010\u03b2RII mice treated with bortezomib and anti\u2010CD20 monoclonal antibody, respectively. Additionally, we performed an adoptive transfer of plasma cells from dnTGF\u2010\u03b2RII mice into C57BL\/6J mice to investigate their pathogenicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In PBC patients, hepatic infiltration of plasma cells and B cells was correlated strongly with liver inflammation and fibrosis, disease staging, and titers of PBC\u2010related autoantibodies. The number of plasma cells (but not B cells) was also higher in UDCA non\u2010responders than in responders.\u00a0Notably, plasma cells depletion in dnTGF\u2010\u03b2RII mice alleviated portal inflammation and reduced levels of AMA, IgM and IgG. Furthermore, the adoptive transfer of plasma cells from dnTGF\u2010\u03b2RII mice into DDC\u2010fed C57BL\/6J mice resulted in AMA production, exacerbated cholestasis, and worsened fibrosis. In contrast, B cell depletion did not alleviate portal inflammation or fibrosis in dnTGF\u2010\u03b2RII mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The data indicate a pathogenic role for plasma cells in PBC. The depletion of plasma cells alleviated cholangitis in PBC mice, indicating a promising new therapeutic strategy for PBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70373","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:40:04Z","timestamp":1759412404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Depletion of Plasma Cells but Not\n                    <scp>CD20<\/scp>\n                    <sup>+<\/sup>\n                    B Cells Alleviates Primary Biliary Cholangitis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2583-8977","authenticated-orcid":false,"given":"Xue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tianjin Medical University General Hospital  Tianjin 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