{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:00:10Z","timestamp":1791846010559,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aims<\/jats:title>\n Primary sclerosing cholangitis (PSC) is a progressive, refractory liver disease often requiring liver transplantation (LT). The association between the disease onset and specific human leukocyte antigen (HLA) typing has been noted, but its relevance in the Japanese population is unknown.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The HLA 5 locus (HLA\u2010A, B, C, DRB1 and DQB1) 4\u2010digit genotyping results of 31 patients with progressive PSC who underwent LT at our institution were compared to those of 873 healthy Japanese controls.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n HLA\u2010B*07:02 (\n p<\/jats:italic>\n \u2010corrected [\n p<\/jats:italic>\n c<\/jats:sub>\n ]\u2009=\u20091.9\u2009\u00d7\u200910\n \u22122<\/jats:sup>\n ), HLA\u2010C*07:02 (\n p<\/jats:italic>\n c<\/jats:sub>\n \u2009=\u20093.9\u2009\u00d7\u200910\n \u22125<\/jats:sup>\n ), HLA\u2010DQB1*05:01 (\n p<\/jats:italic>\n c<\/jats:sub>\n \u2009=\u20093.7\u2009\u00d7\u200910\n \u22122<\/jats:sup>\n ), and HLA\u2010DRB1*01:01 (\n p<\/jats:italic>\n c<\/jats:sub>\n \u2009=\u20091.7\u2009\u00d7\u200910\n \u22122<\/jats:sup>\n ) were identified as the susceptibility alleles for PSC. This correlation was stronger in patients with PSC complicated by ulcerative colitis than in those with PSC alone. Furthermore, analyses of the amino acid sequences of each HLA protein revealed that 15 amino acid residues of HLA\u2010C were significantly associated with disease susceptibility (\n p<\/jats:italic>\n c<\/jats:sub>\n \u2009=\u20091.5\u2009\u00d7\u200910\n \u22124<\/jats:sup>\n \u20104.5\u2009\u00d7\u200910\n \u22124<\/jats:sup>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n HLA\u2010C*07:02 is vulnerable to PSC aggravation in the Japanese population.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.70376","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:06:13Z","timestamp":1761221173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Primary Sclerosing Cholangitis With\n HLA<\/scp>\n \u2010C*07:02 in a Japanese Population"],"prefix":"10.1111","volume":"45","author":[{"given":"Tatsuya","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Pediatric Surgery Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Okajima","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Pediatric Surgery Kanazawa Medical University Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kadohisa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Pediatric Surgery Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Pediatric Surgery Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Yukie","family":"Uebayashi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Pediatric Surgery Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-0011","authenticated-orcid":false,"given":"Katsunori","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Pediatric Surgery Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5892-8317","authenticated-orcid":false,"given":"Takashi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3407-1918","authenticated-orcid":false,"given":"Etsuro","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Pediatric Surgery Kyoto University Hospital Kyoto Japan"},{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.07.005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010018\u20101484\u20109"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.022"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.07.004"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528209182038"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.1.38"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840130119"},{"issue":"1","key":"e_1_2_12_9_1","first-page":"2775","article-title":"HLA Antigens in Primary Sclerosing Cholangitis","volume":"24","author":"Noguchi K.","year":"1992","journal-title":"Transplantation 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Registry by the Japanese Liver Transplantation Society","volume":"45","author":"The Japanese Liver Transplantation Society","year":"2010","journal-title":"Japanese Journal of Transplantation"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.11386\/jst.58.4_339"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.05.048"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.10.011"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114486"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13641"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.13076"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010329524"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.70376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T14:42:54Z","timestamp":1763044974000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.70376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/liv.70376"],"URL":"https:\/\/doi.org\/10.1111\/liv.70376","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,23]]},"assertion":[{"value":"2025-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70376"}}