{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:17:19Z","timestamp":1780759039803,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Palliative care (PC) utilisation is poorly described for patients with advanced hepatocellular carcinoma (HCC), whereas the benefits of PC have been described in a large range of clinical burdens, including prognosis. We aimed to describe the end\u2010of\u2010life (EOL) care pathway and to assess the impact of PC referral on survival after systemic treatment discontinuation in patients with advanced HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EOL care\u2010HCC is a retrospective multicentre study conducted among deceased HCC patients who had received systemic treatment for HCC between January 1, 2016, and December 31, 2021. Baseline characteristics, timing of PC referral and the EOL care pathway after the last treatment administration (LTA) were collected. The primary outcome was time from LTA to death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 224 patients for which the palliative care team (PCT) contact status was known, 49.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009110) met a PCT and 27.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200961) met a PCT before the LTA. The median overall survival after LTA was 7.00\u2009weeks (95% confidence interval 5.56\u20138.26). There was no survival benefit in patients who had contact with PCT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.57), but the median overall survival after LTA was significantly longer if PC referral occurred before the LTA (9.13 vs. 5.34\u2009weeks,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). In multivariate analysis, no difference was observed between both two subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nearly half of patients with advanced HCC met a PCT, without any observed survival benefit. However, early PC referral, before systemic treatment discontinuation, seemed associated with better survival after LTA. PC remains underused and delayed in the advanced HCC care pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70392","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T10:14:53Z","timestamp":1760696093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Palliative Care Referral Practices and Impact on Survival of Patients Diagnosed With Advanced Hepatocellular Carcinoma"],"prefix":"10.1111","volume":"45","author":[{"given":"Antoine","family":"Dupuis","sequence":"first","affiliation":[{"name":"Hepatogastroenterology and Digestive Oncology Department Universit\u00e9 Reims Champagne\u2010Ardenne, CHU Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix","family":"Demory","sequence":"additional","affiliation":[{"name":"Liver Unit H\u00f4pital Universitaire Paris\u2010Seine\u2010Saint\u2010Denis, Assistance\u2010Publique 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Paris\u2010Seine\u2010Saint\u2010Denis, Assistance\u2010Publique H\u00f4pitaux de Paris  Bobigny France"},{"name":"Centre De Recherche Des Cordeliers INSERM \u201cFunctional Genomics of Solid Tumors\u201d  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Perrier","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology and Digestive Oncology Department Universit\u00e9 Reims Champagne\u2010Ardenne, CHU Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Slimano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Universit\u00e9 de Reims Champagne\u2010Ardenne, CHU Reims, BioSpecT  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Palliative Care CHU Reims  Reims 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