{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T23:53:16Z","timestamp":1770162796312,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Implantation of transjugular intrahepatic portosystemic shunt (TIPS) is an important treatment in patients with decompensated cirrhosis. The impact of right ventricular dysfunction on clinical outcomes after TIPS still needs to be defined. The aim of this study was to assess whether echocardiographic measures of right ventricular (RV) function using right ventricular global longitudinal strain (RV\u2010GLS) are predictive of post\u2010TIPS outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who were treated with TIPS implantation and received echocardiographic assessment of right ventricular function, including RV\u2010GLS at two tertiary centers in Germany were included. The primary endpoint was the development of TIPS\u2010refractory ascites. Secondary endpoints included post\u2010TIPS cardiac decompensation, acute\u2010on\u2010chronic liver failure (ACLF) and transplantation\u2010free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 198 patients were included with a median RV\u2010GLS of \u221220.9 [\u221224.6 \u2013 (\u221217.4)]%. There was no correlation between RV\u2010GLS and left ventricular (LV)\u2010GLS. Patients with RV\u2010GLS\u2009&gt;\u2009\u221219% (indicating reduced right ventricular contractility) had a significantly higher risk for TIPS\u2010refractory ascites compared to those with RV\u2010GLS\u2009\u2264\u2009\u221219% (sHR 1.09 [95% CI: 1.04\u20131.16];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) considering liver transplantation and death as competing events. RV\u2010GLS was significantly associated with cardiac decompensation after TIPS (sHR 1.10 [95% CI: 1.02\u20131.17],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). RV\u2010GLS did not independently affect the development of ACLF, but predicted transplantation\u2010free survival (HR 1.10 [1.05\u20131.16],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 adjusted to the FIPS score).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RV strain is an important predictor of post\u2010TIPS outcomes. Functional right heart assessment before TIPS may be a useful tool for risk stratification.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: Freiburg: NCT05782556; Bonn, NCT04393519\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70422","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T08:49:58Z","timestamp":1762591798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Right Ventricular Contractility Predicts Clearance of Ascites After Transjugular Intrahepatic Portosystemic Shunt"],"prefix":"10.1111","volume":"45","author":[{"given":"Lukas A.","family":"Heger","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology, University Heart Center Freiburg\u2010Bad Krozingen, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Berta\u2010Ottenstein\u2010Programme, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Rohrer","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Medical Center University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlene","family":"Reincke","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Medical Center University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Eyth","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Medical Center University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Sturm","sequence":"additional","affiliation":[{"name":"Berta\u2010Ottenstein\u2010Programme, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Department of Medicine II, Medical Center University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schultheiss","sequence":"additional","affiliation":[{"name":"Berta\u2010Ottenstein\u2010Programme, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Department of Medicine II, Medical Center University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Heart Center Freiburg\u2010Bad Krozingen, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Berta\u2010Ottenstein\u2010Programme, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital University Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital University Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-3881","authenticated-orcid":false,"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B, University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Westermann","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Heart Center Freiburg\u2010Bad Krozingen, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Thimme","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Medical Center University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Grundmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Heart Center Freiburg\u2010Bad Krozingen, Faculty of Medicine University of Freiburg  Freiburg 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