{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:54:51Z","timestamp":1781646891360,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The effectiveness and safety of medications for alcohol use disorder (MAUD) in treating alcohol\u2010associated cirrhosis have not been fully elucidated. This study aims to explore the clinical benefits and risks of MAUD in patients with alcohol\u2010associated cirrhosis and persistent alcohol use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study utilised anonymised electronic health records (EHRs) from the TriNetX platform to evaluate the impact of MAUD on mortality, alcohol abstinence rates, hepatocellular carcinoma, hepatic decompensation and healthcare utilisation in patients with alcohol\u2010associated cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study evaluated 200\u2009054 patients with alcohol\u2010associated cirrhosis; after propensity score matching, 17\u2009548 patients (8774 in each group) were analysed comparing those treated with MAUD to those without. At 3\u2009years, patients treated with MAUD exhibited significantly lower mortality (21.6% vs. 29.3%, HR 0.731, 95% CI 0.688\u20130.776,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), reduced hepatocellular carcinoma (2.6% vs. 3.3%, HR 0.794,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) and fewer hospitalisations (16.7% vs. 24.8%, HR 0.635,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Subgroup analyses revealed that among 5083 patients treated with naltrexone, 3\u2010year mortality was reduced (19.8% vs. 30.3%, HR 0.645, 95% CI 0.596\u20130.699,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), hepatocellular carcinoma incidence was lower (2.6% vs. 3.3%, HR 0.790,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) and hepatic decompensation decreased (18.4% vs. 21.1%, HR 0.843,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Among 4108 patients treated with acamprosate, 3\u2010year mortality was reduced (22.6% vs. 29.0%, HR 0.799, 95% CI 0.733\u20130.871,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and hospitalisations and emergency department visits were significantly lower, though no reduction in hepatocellular carcinoma was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates the significant benefits of MAUD in patients with alcohol\u2010associated cirrhosis, including reduced mortality, lower healthcare utilisation and improved alcohol abstinence rates, supporting its integration into standard care protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70424","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T10:10:27Z","timestamp":1762337427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating the Long\u2010Term Benefits of Medications for Alcohol Use Disorder in Alcohol\u2010Associated Cirrhosis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5610-5897","authenticated-orcid":false,"given":"Chengu","family":"Niu","sequence":"first","affiliation":[{"name":"Internal Medicine Residency Program Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rainier Springs Behavioral Health Hospital  Vancouver Washington 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