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A prospective compensated advanced chronic liver disease (cACLD) cohort was used to explore the capability of ICG\u2010R15 in the differentiation of CSPH as referenced by hepatic venous pressure gradient (HVPG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Performance of ICG\u2010R15 alone and combined with Baveno VII algorithm for CSPH differentiation was established with a monocentric set and validated with a bicentric set of patients with HVPG assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the training set (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200996), ICG\u2010R15\u2009\u2265\u200914% could identify 63.6% (28\/44) CSPH with 96.2% specificity and 93.3% positive predictive value (PPV). ICG\u2010R15\u2009&lt;\u20094% was able to exclude 40.4% (21\/52) non\u2010CSPH with 95.5% sensitivity and 91.3% negative predictive value (NPV). In the validation set (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009106), ICG\u2010R15\u2009\u2265\u200914% could identify 63.6% (28\/44) CSPH with 95.2% specificity and 90.3% PPV. ICG\u2010R15\u2009&lt;\u20094% could exclude 41.9% (26\/62) non\u2010CSPH with 95.5% sensitivity and 92.9% NPV. Sensitivity analysis in the total set of patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009202) reinforced robustness. Combined ICG\u2010R15\u2009\u2265\u200914% with LSM\u2009\u2265\u200925\u2009kPa improved performance with 72.7% (64\/88) sensitivity, 85.3% PPV and 90.4% specificity. Meanwhile, ICG\u2010R15\u2009&lt;\u20094% with LSM\u2009\u2264\u200915\u2009kPa plus platelet count \u2265\u2009150\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L excluded CSPH with 95.5% sensitivity and 94.5% NPV, reducing diagnosis uncertainty (grey zone) to 26.7%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PDD\u2010estimated ICG\u2010R15\u2009\u2265\u200914% could identify CSPH and ICG\u2010R15\u2009&lt;\u20094% to exclude CSPH in cACLD patients. ICG\u2010R15 sequential with Baveno VII enhanced diagnostic capability, warranting multicentre validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>NCT04123509, NCT04820166 and NCT05251272<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70425","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:47:14Z","timestamp":1762163234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Indocyanine Green Clearance Test via Pulse Dye Densitometry for Portal Hypertension Diagnosis in\n                    <scp>cACLD<\/scp>"],"prefix":"10.1111","volume":"45","author":[{"given":"Miaoxia","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hepatology Unit and Infectious Diseases Nanfang Hospital, Southern Medical University  Guangzhou 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