{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:50:28Z","timestamp":1777042228969,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The clinical relevance of diastolic dysfunction (DD), as defined by the revised 2020 Cirrhotic Cardiomyopathy (CCM) guidelines, in patients with decompensated cirrhosis undergoing TIPS remains unclear. We aimed to evaluate the association between 2020 CCM DD criteria and post\u2010TIPS outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a multicenter retrospective study of adults who underwent TIPS between 2018 and 2022. Patients with recorded parameters to assess 2020 CCM DD (\u2265\u20093 of:\n                      <jats:italic>E<\/jats:italic>\n                      \/\n                      <jats:italic>e<\/jats:italic>\n                      \u2032 \u2265\u200915, septal\n                      <jats:italic>e<\/jats:italic>\n                      \u2032 velocity &lt;\u20097\u2009cm\/s, tricuspid regurgitation velocity &gt;\u20092.8\u2009m\/s, left atrial volume index &gt;\u200934\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) within 6\u2009months prior to TIPS were included and compared to 2005 DD criteria (deceleration time\u2009&gt;\u2009200\u2009ms, isovolumetric relaxation time\u2009&gt;\u200980\u2009ms,\n                      <jats:italic>E<\/jats:italic>\n                      \/\n                      <jats:italic>A<\/jats:italic>\n                      \u2009&lt;\u20091). Logistic regression models assessed post\u2010TIPS outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 261 patients, 18 (6.9%) met the 2020 CCM DD criteria. These patients were older (67 vs. 59\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and had higher rates of hypertension (66% vs. 39%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024) and MASLD (55% vs. 25.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Although not associated with mortality, those meeting the 2020 CCM DD criteria had higher odds of developing cardiovascular events (adjusted OR 6.7, 95% CI 1.8\u201323.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), renal dysfunction (adjusted OR 3.7, 95% CI 1.2\u201310.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), and liver dysfunction (adjusted OR 7.4, 95% CI 2.3\u201323.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). 75.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009198) met the 2005 DD criteria and showed no association with outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DD defined by the 2020 CCM criteria, but not the 2005 criteria, was associated with significantly higher odds of early post\u2010TIPS complications. Patients meeting 2020 CCM DD criteria were associated with older age, hypertension, MASLD, and beta\u2010blocker use, and may benefit from close post\u2010TIPS monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70469","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:35:12Z","timestamp":1765280112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pre\u2010TIPS Diastolic Dysfunction as a Predictor of Post\u2010TIPS Outcomes in Patients With Cirrhosis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7403-2561","authenticated-orcid":false,"given":"Shoma","family":"Bommena","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Arizona College of Medicine\u2010Tucson, Banner University Medical Center  Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Patel","sequence":"additional","affiliation":[{"name":"University of Arizona College of Medicine\u2010Phoenix  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja","family":"Rangan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Arizona College of Medicine\u2010Phoenix, Banner University Medical Center  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Fallon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Arizona College of Medicine\u2010Phoenix, Banner University Medical Center  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/LVT.0000000000000458"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2021.01.012"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-022-07580-y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.26460"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30875"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30934"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew082"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2024.101568"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12471"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002151"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000691"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17695"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2115"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.029"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1549376"},{"issue":"2","key":"e_1_2_10_17_1","first-page":"230","article-title":"What Constitutes Liver Failure After Transjugular Intrahepatic Portosystemic Shunt Creation? 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