{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:05:29Z","timestamp":1789758329080,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special Fund","doi-asserted-by":"publisher","award":["2022\u20102\u20102029"],"award-info":[{"award-number":["2022\u20102\u20102029"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Steatotic liver disease (SLD) is increasingly identified in pregnant populations. However, its associations with adverse pregnancy outcomes (APOs) in relation to specific trimesters remain unclear. This study aimed to evaluate the trimester\u2010specific associations between SLD and APOs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 3806 pregnant women from Beijing Friendship Hospital.\u00a0Hepatic ultrasonography was performed to assess SLD status during the first (T1) and third (T3) trimesters. Associations between SLD and APOs were assessed using logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of SLD among pregnant women was 10.27%, varying across trimesters. Persistent SLD (present in both T1 and T3) demonstrated positive associations with overall APOs (OR\u2009=\u20091.728, 95% CI: 1.202\u20132.502,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), including pregnancy\u2010associated hypertension (OR\u2009=\u20091.742; 95% CI: 1.019\u20132.916;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038), preterm birth (OR\u2009=\u20092.552, 95% CI: 1.019\u20135.965,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037), and large\u2010for\u2010gestational\u2010age neonates (OR\u2009=\u20091.762, 95% CI: 1.080\u20132.820,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020). T1 SLD (OR\u2009=\u20091.737, 95% CI: 1.128\u20132.700,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) and persistent SLD (OR\u2009=\u20091.821, 95% CI: 1.282\u20132.600,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were both associated with a higher risk of caesarean section. Notably, T3 SLD was significantly associated with postpartum haemorrhage (OR\u2009=\u20092.154; 95% CI: 1.025\u20134.078;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). A marginal association was observed between pregnancy\u2010associated hypertension and T3 SLD (OR\u2009=\u20092.024; 95% CI: 0.965\u20133.876;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Persistent SLD in pregnancy is associated with an increased risk of APOs, trimester\u2010specific assessment of SLD may facilitate risk stratification and inform clinical management. Further studies are warranted to evaluate whether lifestyle interventions can mitigate these risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70471","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T10:51:25Z","timestamp":1765277485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Trimester\u2010Specific Impacts of Steatotic Liver Disease on Adverse Pregnancy Outcomes: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"46","author":[{"given":"Lei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2683-8552","authenticated-orcid":false,"given":"Shuhan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-5958","authenticated-orcid":false,"given":"Antje","family":"Hebestreit","sequence":"additional","affiliation":[{"name":"Department of Epidemiological Methods and Etiological Research Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS  Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health Peking University  Beijing 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