{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:53:12Z","timestamp":1774277592722,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["JP\u201024K02523"],"award-info":[{"award-number":["JP\u201024K02523"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Patatin\u2010like phospholipase domain 3 (\n                      <jats:italic>PNPLA3<\/jats:italic>\n                      ) I148M (rs738409 C&gt;G) variant has been reported as a risk factor for metabolic dysfunction\u2010associated steatotic liver disease\/steatohepatitis and contributes to hepatic fibrosis and hepatocellular carcinoma (HCC); however, its role in recurrence after liver resection remains unclear. This study aimed to evaluate the effect of\n                      <jats:italic>PNPLA3<\/jats:italic>\n                      variants on HCC recurrence after liver resection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred sixteen patients with non\u2010viral HCC who underwent curative liver resection were retrospectively analysed.\n                      <jats:italic>PNPLA3<\/jats:italic>\n                      rs738409 genotype was identified using blood\u2010derived genomic DNA. Recurrence\u2010free survival (RFS) was compared across genotypes, and multivariate analysis was performed to identify the independent risk factors for recurrence. Postoperative changes in fibrosis indexes over 2\u2009years were also evaluated according to genotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The number of patients in each PNPLA3 genotype group was as follows: CC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), CG (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955) and GG (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941). The CG\/GG group showed significantly poorer RFS than the CC group, and multivariate analysis identified the\n                      <jats:italic>PNPLA3<\/jats:italic>\n                      CG\/GG genotype as an independent risk factor, especially for late recurrence. To better evaluate the effect on the remnant liver, patients with early recurrence were excluded from the study. In the CG\/GG group, the fibrosis indices worsened over the 2\u2009years following surgery, whereas they remained stable in the CC group. Among the patients with CG\/GG, those with worsening fibrosis had a significantly higher rate of late recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Patients with the\n                      <jats:italic>PNPLA3<\/jats:italic>\n                      CG\/GG genotype, especially those with progressive fibrosis, have a high risk of recurrence after liver resection.\n                      <jats:italic>PNPLA3<\/jats:italic>\n                      genotyping may help identify patients at high risk of late recurrence who require careful long\u2010term surveillance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70531","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:45:35Z","timestamp":1770237935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patatin\u2010Like Phospholipase Domain Containing 3\n                    <scp>I<\/scp>\n                    148\n                    <scp>M<\/scp>\n                    Variant Affects Hepatocellular Carcinoma Recurrence After Liver Resection"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-3209","authenticated-orcid":false,"given":"Yuki","family":"Nakayama","sequence":"first","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-5649","authenticated-orcid":false,"given":"Kazuki","family":"Takeishi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery National Hospital Organization Kyushu Medical Center  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0382-2520","authenticated-orcid":false,"given":"Shinji","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Motomura","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-8288","authenticated-orcid":false,"given":"Takeo","family":"Toshima","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-7913","authenticated-orcid":false,"given":"Kyohei","family":"Yugawa","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4684-1617","authenticated-orcid":false,"given":"Takahiro","family":"Tomiyama","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriko","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Toshida","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Mita","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-9126","authenticated-orcid":false,"given":"Takeshi","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Department of Pathology, Center for Transcriptional Medicine. 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