{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:58:54Z","timestamp":1788479934002,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015738","name":"Mary och Georg C. 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The reason some patients with MASLD develop metabolic dysfunction\u2010associated steatohepatitis (MASH) and which metabolic changes in the liver are linked to its progression are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A non\u2010targeted metabolomics analysis was performed on liver samples from 106 Finnish patients with severe obesity (71 females, mean age\u2009\u00b1\u2009SD: 48.6\u2009\u00b1\u20098.7\u2009years, body mass index: 41.6\u2009\u00b1\u20095.2\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) selected for laparoscopic gastric bypass surgery. Liver metabolomics and liver RNA sequencing data were used to study metabolic differences between those with steatosis and those with MASH. Validation was performed in a French cohort of 227 patients with obesity and MASLD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 45 metabolites differed between patients with steatosis and those with MASH. Novel MASH\u2010associated metabolites included\n                      <jats:sc>n<\/jats:sc>\n                      \u2010acetylneuraminate (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.276), pentose acid (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.290), UDP\u2010galactose (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.413), gamma\/beta\u2010tocopherol (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.317), and guanidinosuccinate (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.289) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In the validation cohort, 8 of 20 metabolites, including\n                      <jats:sc>n<\/jats:sc>\n                      \u2010acetylneuraminate and plasmalogens 1\u2010(1\u2010enyl\u2010palmitoyl)\u20102\u2010arachidonoyl\u2010GPE(P\u201016:0\/20:4) and 1\u2010(1\u2010enyl\u2010stearoyl)\u20102\u2010arachidonoyl\u2010GPE(P\u201018:0\/20:4), were linked to MASH (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The 45 significantly altered metabolites formed two clusters with different associations with metabolic parameters, depending on their correlation with liver histological features. Kyoto Encyclopedia of Genes and Genomes analysis revealed that elevated metabolites in MASH were associated with inflammatory pathways; those decreased in MASH were linked to fatty acid degradation and amino acid and pyruvate metabolism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transitioning from simple steatosis to MASH is associated with distinct alterations in liver metabolites and systemic metabolic traits, highlighting disease progression\u2010associated pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70552","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:56:56Z","timestamp":1770962216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Liver Metabolomic Profiling Reveals Distinct Signatures Between Steatosis and Metabolic Dysfunction\u2010Associated Steatohepatitis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-8932","authenticated-orcid":false,"given":"Saana","family":"Palomurto","sequence":"first","affiliation":[{"name":"Department of Surgery Kuopio University Hospital, North Savo Wellbeing County  Kuopio Finland"},{"name":"School of Medicine Institute of Clinical Medicine, University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Flam","sequence":"additional","affiliation":[{"name":"University of Lille, Inserm, CHU Lille, Institut Pasteur Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Kaminska","sequence":"additional","affiliation":[{"name":"Department of Human Genetics David Geffen School of Medicine at UCLA  Los Angeles California USA"},{"name":"Institute of Public Health and Clinical Nutrition, School of Medicine University of Eastern Finland  Kuopio Finland"},{"name":"Division of Digestive Diseases David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi A.","family":"Virtanen","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesa","family":"K\u00e4rj\u00e4","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Kuopio University Hospital, North Savo Wellbeing County  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo","family":"K\u00e4kel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Surgery Kuopio University Hospital, North Savo Wellbeing County  Kuopio Finland"},{"name":"School of Medicine Institute of Clinical Medicine, University of Eastern Finland  Kuopio 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