{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:30:32Z","timestamp":1777480232928,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006544","name":"Ministry of Health, State of Israel","doi-asserted-by":"publisher","award":["3\u20100000\u201016286"],"award-info":[{"award-number":["3\u20100000\u201016286"]}],"id":[{"id":"10.13039\/501100006544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>The pathogenesis of metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is multifactorial, with evidence suggesting a protective role for the soluble receptor for advanced glycation end\u2010products (sRAGE). While gut microbiota dysbiosis and MASLD have been linked, evidence of their association with sRAGE remains limited. We aimed to test the prospective association between serum sRAGE levels and MASLD and to explore associated patterns of gut microbiota composition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study assessed serum sRAGE levels and MASLD at two time points, with new\u2010onset or persistence of MASLD evaluated by ultrasonography or controlled attenuation parameter. A cross\u2010sectional analysis was performed on a sub\u2010sample with gut microbiota measurements using 16S rRNA sequencing (V3\u2010V4, Illumina MiSeq).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 289 subjects in the prospective analysis (mean follow\u2010up: 6.67\u2009\u00b1\u20090.73\u2009years, mean age: 58.54\u2009\u00b1\u20096.54\u2009years, 57.8% men), low sRAGE levels were associated with 2.22\u2010fold greater odds of new\u2010onset\/persistent MASLD (95% CI 1.15\u20134.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), with a dose\u2013response association across sRAGE tertiles. The cross\u2010sectional analysis with a subsample of 136 subjects showed significant\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010 and\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010diversity differences between MASLD and non\u2010MASLD groups. Moreover, \u03b2\u2010diversity variation across sRAGE groups resembled that observed between the MASLD groups. Shared taxa linked to low sRAGE levels and MASLD included Streptococcaceae, Enterobacteriaceae,\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      ,\n                      <jats:italic>Dorea<\/jats:italic>\n                      , and\n                      <jats:italic>Klebsiella<\/jats:italic>\n                      . Non\u2010MASLD and high sRAGE levels were associated with Christensenellaceae, Akkermansiaceae,\n                      <jats:italic>Christensenellaceae R\u20107 group<\/jats:italic>\n                      and\n                      <jats:italic>Akkermansia<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low sRAGE levels are associated with higher odds of MASLD. MASLD and low sRAGE levels share a similar gut microbiota signature, suggesting a potential biological link that warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70553","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:09:49Z","timestamp":1770955789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low Serum\n                    <scp>sRAGE<\/scp>\n                    and\n                    <scp>MASLD<\/scp>\n                    Are Associated and Share a Similar Gut Microbiota Profile: A Prospective and Cross\u2010Sectional Analysis"],"prefix":"10.1111","volume":"46","author":[{"given":"Laura Sol","family":"Grinshpan","sequence":"first","affiliation":[{"name":"School of Public Health, Faculty of Social Welfare and Health Sciences University of Haifa  Haifa Israel"},{"name":"Department of Gastroenterology Tel Aviv Medical 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