{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:52:57Z","timestamp":1774277577517,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["IN\u2010US\u2010334\u20104309"],"award-info":[{"award-number":["IN\u2010US\u2010334\u20104309"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background & Aims<\/jats:title>\n Direct\u2010acting antiviral agents (DAA)\u2010mediated HCV cure correlates with better outcomes, but there are insufficient data on detailed mortality\u2010related risk factors after cure. This study sought to clarify mortality and associated risk factors post\u2010HCV cure.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The study included HCV patients with sustained virological response following DAA (DAA\u2010SVR) from 39 REAL\u2010C centres in North America, Europe and Asia\u2010Pacific. The primary outcome was all\u2010cause mortality in DAA\u2010SVR patients. Mortality rate per 1000 patient\u2010years (PY) was calculated as the number of deaths divided by total PY multiplied by 1000.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 10\u2009034 DAA\u2010SVR patients (stratified by cirrhosis status: 5611 non\u2010cirrhosis, 4153 compensated, 270 decompensated) were included. With a median follow\u2010up of 4.76 PY, 4.9% (491) died. The all\u2010cause mortality rates were 6.2, 13.1, 60.0 and 10.4 per 1000 PY for patients without cirrhosis, compensated and decompensated cirrhosis, and overall patients, respectively. The 5\u2010year cumulative survival was 95.1% (94.5%\u201395.6%) overall, with the lowest rate of 73.9% (67.0%\u201379.5%) in decompensated cirrhosis. Non\u2010liver\u2010related death was the main cause in non\u2010cirrhosis (non\u2010liver\u2010related vs. liver: 5.2 vs. 0.8 per 1000 PY)\/compensated cirrhosis (8.2 vs. 4.8 per 1000 PY), while liver\u2010related death was dominant in decompensated cirrhosis (24.7 vs. 33.8 per 1000 PY). Risk factors for higher mortality included age\u2009>\u200965 (3.2\u2010fold), male (1.5\u2010fold), cirrhosis (decompensated 7.6\u2010fold) and baseline DM (1.5\u2010fold).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study showed significant age, sex, fibrosis stage and DM differences in mortality and causes among DAA\u2010SVR patients. It provided granular subgroup data for precision medicine to support individualised care, future modelling studies and public health planning.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.70561","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T04:10:27Z","timestamp":1771819827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Mortality Following Hepatitis C Cure in a Real\u2010World Multinational Cohort"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1463-8035","authenticated-orcid":false,"given":"Fanpu","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Hepatology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Tran","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Stanford University Medical Center Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ogaki Municipal Hospital Ogaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Osaka Metropolitan University Graduate School of Medicine Osaka Japan"},{"name":"Department of Hepatology Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine Kyushu University Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-068X","authenticated-orcid":false,"given":"Chung\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-1183","authenticated-orcid":false,"given":"Yu Jun","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology Changi General Hospital, SingHealth Changi Singapore"},{"name":"SingHealth Duke\u2010NUS Medicine Academic Clinical Program Duke Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Chuma","sequence":"additional","affiliation":[{"name":"Gastroenterological Center Yokohama City University Medical Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Uojima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine Kitasato University School of Medicine Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3374-7111","authenticated-orcid":false,"given":"Masanori","family":"Atsukawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8984-5103","authenticated-orcid":false,"given":"Yao\u2010Chun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine E\u2010Da Cancer Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2875-6139","authenticated-orcid":false,"given":"Dae Won","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University, College of Medicine Seoul Korea"},{"name":"Hanyang Institute of Bioscience and Biotechnology Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akito","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Gastroenterological Center Yokohama City University Medical Center Yokohama 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