{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:51:47Z","timestamp":1791647507819,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Drug\u2010induced liver injury (DILI) with severe DRESS carries high mortality, yet rescue therapies for corticosteroid\u2010refractory cases remain undefined. We hypothesized that JAK inhibition could reverse refractory liver injury by targeting the underlying cytokine storm. In this prospective proof\u2010of\u2010concept study, consecutive patients with severe DRESS\u2010associated DILI refractory to corticosteroids (persistent\/worsening liver injury) received oral tofacitinib rescue. Key assessments were the normalisation of liver biochemistries. Despite initial corticosteroids, all four patients exhibited progressive severe injury (median peak ALT 1126\u2009U\/L). Tofacitinib rapidly reversed liver injury in all cases. Transaminases normalised or near\u2010normalised (median: 48\u2009days), total bilirubin normalised, and cutaneous symptoms resolved completely. Notably, baseline positive autoantibodies seroconverted to negative. No severe adverse events occurred (median follow\u2010up: 274\u2009days). Tofacitinib shows promise as a rescue strategy for corticosteroid\u2010refractory DILI with severe DRESS. The rapid recovery underscores the JAK\u2013STAT pathway's pathogenic role in this setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70578","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:40:02Z","timestamp":1773394802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tofacitinib Rescue for Refractory Drug\u2010Induced Liver Injury With Severe\n                    <scp>DRESS<\/scp>\n                    : A Prospective Proof\u2010of\u2010Concept Study"],"prefix":"10.1111","volume":"46","author":[{"given":"Jingyan","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University Third Hospital  Beijing 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Dermatology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8762-0274","authenticated-orcid":false,"given":"Wenhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University Third Hospital  Beijing 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