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Emerging evidence highlights bile acids (BAs) as pivotal signalling molecules that modulate genes involved in their own metabolism and lipid homeostasis in hepatic and extrahepatic tissues, thereby influencing MASLD pathogenesis. These regulatory effects are primarily driven by the activation of nuclear receptors, including the farnesoid X receptor (FXR), vitamin D receptor (VDR), pregnane X receptor (PXR), and by the membrane\u2010bound G protein\u2010coupled receptors such as Takeda G protein\u2010coupled receptor 5 (TGR5) and sphingosine\u20101\u2010phosphate receptor 2 (S1PR2). The distinct roles of these BA receptor\u2010dependent signalling pathways in lipid homeostasis underscore their importance in MASLD development. Pharmacological strategies targeting BA\u2010regulated pathways, particularly the FXR activation, have shown promise in MASLD treatment. Several FXR agonists, including obeticholic acid (OCA), cilofexor, and tropifexor, have progressed to clinical trials, demonstrating potential therapeutic efficacy. Additionally, recent studies identified several natural compounds\u2014such as hyperoside, kaempferol, and salidroside\u2014that exhibited direct or indirect FXR\u2010modulating properties, suggesting their potential utility for novel anti\u2010MASLD drug development. Further research into BA signalling mechanisms and the exploration of targeted therapies may provide novel and effective MASLD therapy.<\/jats:p>","DOI":"10.1111\/liv.70586","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:12:06Z","timestamp":1773234726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An Update on Bile Acid\u2010Regulated Signalling in the Pathogenesis of Metabolic Dysfunction\u2010Associated Steatotic Liver Disease"],"prefix":"10.1111","volume":"46","author":[{"given":"Jiang\u2010Shan","family":"Shi","sequence":"first","affiliation":[{"name":"College of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wen","sequence":"additional","affiliation":[{"name":"College of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Integrative Medicine The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Juan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Integrative Medicine The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-534X","authenticated-orcid":false,"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University  Luzhou Sichuan China"},{"name":"School of Biomedical Sciences University of Queensland  St Lucia Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-176X","authenticated-orcid":false,"given":"Hong\u2010Lian","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Integrative Medicine The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo14010012"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415489"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.05.011"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1127483"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093143"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1089359"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c170012"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci118645"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0029665118002653"},{"key":"e_1_2_13_12_1","first-page":"217","volume-title":"Endotext","author":"Feingold K. 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