{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:48:43Z","timestamp":1775886523107,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Terlipressin is crucial for treating acute oesophageal variceal bleeding (AEVB) and hepatorenal syndrome (HRS). This meta\u2010analysis compared the continuous versus bolus terlipressin infusion for treating the above conditions in patients with cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three major databases were searched for randomised controlled trials (RCTs) comparing two infusion strategies. A meta\u2010analysis was conducted to estimate the risk ratios (RR) with a 95% confidence interval (CI) based on a random\u2010effects model. Subgroup analyses were performed to account for adverse events (AEs) in terms of severity and organ systems. Additionally, a dose\u2013response analysis was conducted to evaluate the correlation between drug dosage and AEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Six RCTs (494 patients) were included. Compared with bolus infusion, continuous terlipressin infusion showed less treatment failure (RR, 0.32; 95% CI, 0.12\u20130.87;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), less rebleeding (RR, 0.52; 95% CI, 0.33\u20130.81;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and a trend toward lower mortality (RR, 0.62; 95% CI, 0.30\u20131.28;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.19) in patients with AEVB, while response rates were comparable in patients with HRS (RR, 1.11; 95% CI, 0.87\u20131.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.40) and a risk reduction of total AEs (RR, 0.59; 95% CI, 0.45\u20130.76;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Subgroup analyses stratifying AEs supported these findings, and a correlation was noted between drug dose and cardiovascular AEs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared to bolus administration, continuous terlipressin infusion reduces treatment failure and rebleeding rates in patients with AEVB; provides a comparable response rate in patients with HRS; and decreases the incidence of total, severe, and cardiovascular AEs while allowing for lower overall doses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70607","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:02:58Z","timestamp":1773910978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous Versus Bolus Terlipressin for Acute Oesophageal Variceal Bleeding and Hepatorenal Syndrome in Cirrhosis: Meta\u2010Analysis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6070-0178","authenticated-orcid":false,"given":"Ping\u2010Han","family":"Hsieh","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Koo Foundation Sun Yat\u2010Sen Cancer Center  Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5144-2066","authenticated-orcid":false,"given":"Tsung\u2010Chieh","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Therapeutic and Research Center of Liver Cirrhosis and Portal Hypertension, Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4903-942X","authenticated-orcid":false,"given":"Enoch Yi\u2010No","family":"Kang","sequence":"additional","affiliation":[{"name":"Evidence\u2010Based Medicine Center, Wan Fang Hospital, Taipei Medical University  Taipei Taiwan"},{"name":"Institute of Health Policy and Management, College of Public Health, National Taiwan University  Taipei Taiwan"},{"name":"Cochrane Taiwan, Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6463-430X","authenticated-orcid":false,"given":"Yu\u2010Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Therapeutic and Research Center of Liver Cirrhosis and Portal Hypertension, Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7492-2484","authenticated-orcid":false,"given":"Pei\u2010Chang","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Therapeutic and Research Center of Liver Cirrhosis and Portal Hypertension, Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4318-5511","authenticated-orcid":false,"given":"Kuei\u2010Chuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Therapeutic and Research Center of Liver Cirrhosis and Portal Hypertension, Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4631-9450","authenticated-orcid":false,"given":"Hui\u2010Chun","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Therapeutic and Research Center of Liver Cirrhosis and Portal Hypertension, Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Endoscopy Center for Diagnosis and Treatment, Department of Medicine, Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4306-5464","authenticated-orcid":false,"given":"Jiing\u2010Chyuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4886-0718","authenticated-orcid":false,"given":"Ming\u2010Chih","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Therapeutic and Research Center of Liver Cirrhosis and Portal Hypertension, Taipei Veterans General Hospital  Taipei 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